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Orexin Antibody (PA5-67575) in IHC (P)
Immunohistochemical analysis of Orexin in paraffin-embedded Human colorectal cancer tissue using (left) Orexin Polyclonal Antibody (Product # PA5-67575) at a 1:25 dilution and (right) is treated with synthetic peptide. (Original magnification: x200).
Product Details
PA5-67575
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human Orexin.
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Purification
affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2688465
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hcrt; Hypocretin; Hypocretin (orexin) neuropeptide; Hypocretin neuropeptide precursor; orexin; orexin A; orexin B; Orexin precursor; Prepro-orexin; Preprohypocretin
Gene Aliases: HCRT; NRCLP1; orexin-A; OX; PPORX; PPOX
UniProt ID: (Human) O43612, (Mouse) O55241, (Rat) O55232
Entrez Gene ID: (Human) 3060, (Mouse) 15171, (Rat) 25723
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
protein kinase C-activating G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
chemical synaptic transmission
negative regulation of DNA replication
eating behavior
negative regulation of potassium ion transport
regulation of neurotransmitter secretion
positive regulation of calcium ion transport
negative regulation of transmission of nerve impulse
positive regulation of transmission of nerve impulse
excitatory postsynaptic potential
temperature homeostasis
feeding behavior
behavioral fear response
release of sequestered calcium ion into cytosol
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