Proteintech

Oxytocin Receptor Polyclonal Antibody

Oxytocin Receptor Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Oxytocin Receptor Antibody (23045-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human hysteromyoma tissue slide using 23045-1-AP ( Oxytocin Receptor antibody at dilution of 1:50 (under 40x lens).

Oxytocin Receptor Antibody in Western Blot (WB)

Oxytocin Receptor Antibody in Flow Cytometry (Flow)

Oxytocin Receptor Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

23045-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 5 publications 5 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse, Pig

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Oxytocin Receptor Fusion Protein Ag19074 (326-389 aa encoded by BC137443)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.39 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is raised against the C-terminal region of human OXTR.

Immunogen sequence: PWIYMLFTG HLFHELVQRF LCCSASYLKG RRLGETSASK KSNSSSFVLS HRSSSQRSCS QPSTA (326-389 aa encoded by BC137443)

Target Information

The oxytocin receptor (OXTR) belongs to the G-protein coupled receptor family. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The receptor is made up of 389 amino acids and has a molecular weight of ~43,000 kDa. The oxytocin-oxytocin receptor system plays an important role as an inducer of uterine contractions during parturition and of milk ejection. Oxytocin receptors are expressed by the myoepithelial cells of the mammary gland, and in both the myometrium and endometrium or the uterus at the end of pregnancy. Additionally, oxytocin receptors are present in the central nervous system, mediating a variety of behaviors, including maternal behavior, bonding, social memory and recognition, sexual and aggressive behaviors, and stress and anxiety.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Co-culture of iNeurons with primary human skin cells provides a reliable model to examine intercellular communication.

Journal of cosmetic dermatology

Labarrade F,Botto JM,Imbert I

Sat Jul 01 00:00:00 UTC 2023

Phloroglucinol inhibits oxytocin-induced contraction in rat gastric circular muscle and uterine smooth muscle.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

Yang W,Guo H,Niu J,Liu J,Su R,Bai Y,Zhang S,Liu Q,Sun N

Fri Dec 01 00:00:00 UTC 2023

Metabonomics profile analysis in inflammation-induced preterm birth and the potential role of metabolites in regulating premature cervical ripening.

Reproductive biology and endocrinology : RB&E

Yan Y,Gu Z,Li B,Guo X,Zhang Z,Zhang R,Bian Z,Qiu J

Tue Sep 06 00:00:00 UTC 2022

Synergistic antitumor activity of 5-fluorouracil and atosiban against microsatellite stable colorectal cancer through restoring GATA3.

Biochemical pharmacology

Wang M,Guo X,Yang M,Zhang Y,Meng F,Chen Y,Chen M,Qiu T,Li J,Li Z,Zhang Q,Xu F,Zhang H,Wang W

Sun May 01 00:00:00 UTC 2022

Prognostic role of oxytocin receptor in colon adenocarcinoma.

Open medicine (Warsaw, Poland)

Sun J,Xu Z,Mao Y,Zhang T,Qin Y,Hua D

Sat Dec 11 00:00:00 UTC 2021

Oxytocin Facilitates Dentinogenesis of Rat Dental Pulp Cells.

Journal of endodontics

Kato Y,Yokose S

Thu Apr 01 00:00:00 UTC 2021

The Role of Formyl Peptide Receptor 1 in Uterine Contraction During Parturition.

Frontiers in pharmacology

Chen C,Zhu S,Bai L,Sui M,Chen D

Tue Aug 17 00:00:00 UTC 2021

Oxytocin modulates neural processing of mitral/tufted cells in the olfactory bulb.

Acta physiologica (Oxford, England)

Sun C,Yin Z,Li BZ,Du H,Tang K,Liu P,Hang Pun S,Lei TC,Li A

Thu Apr 01 00:00:00 UTC 2021

ΔMST and the Regulation of Cardiac CSE and OTR Expression in Trauma and Hemorrhage.

Antioxidants (Basel, Switzerland)

Trautwein B,Merz T,Denoix N,Szabo C,Calzia E,Radermacher P,McCook O

Wed Feb 03 00:00:00 UTC 2021

Maternal Separation Induces Long-Term Alterations in the Cardiac Oxytocin Receptor and Cystathionine γ-Lyase Expression in Mice.

Oxidative medicine and cellular longevity

Wigger DC,Gröger N,Lesse A,Krause S,Merz T,Gündel H,Braun K,McCook O,Radermacher P,Bock J,Waller C

Wed Sep 30 00:00:00 UTC 2020

Cerebral Immunohistochemical Characterization of the H₂S and the Oxytocin Systems in a Porcine Model of Acute Subdural Hematoma.

Frontiers in neurology