Invitrogen

P-Glycoprotein Polyclonal Antibody

View all (102) P-Glycoprotein (ABCB1) antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-119958

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide within human P Glycoprotein aa 733-756/1,280
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

TBS, pH 7.4, with 50% glycerol, 0.2% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2913530

Product Specific Information

Positive Control: HepG2 cell lysate, Hela cell lysate, human kidney tissue, human small intestine tissue, human thyroid carcinoma tissue, mouse kidney tissue, rat brain tissue.

Subcellular Location: Cell membrane, Apical cell membrane.

Target Information

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1); ATP-binding cassette sub-family B member 1; ATP-binding cassette sub-family B member 1A; ATP-binding cassette sub-family B member 1B; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1); ATP-binding cassette, sub-family B (MDR/TAP), member 1A; ATP-binding cassette, sub-family B (MDR/TAP), member 1B; ATP-binding cassette, sub-family B (MDR/TAP), member 4; ATP-binding cassette, subfamily B (MDR/TAP), member 1A; ATP-binding cassette, subfamily B, member 1A; ATP-binding cassette, subfamily B, member 1B; ATP-dependent translocase ABCB1; CD243; colchicin sensitivity; doxorubicin resistance; ecotropic viral integration site 32; MDR1A; multi-drug resistance 3; Multidrug resistance protein 1; Multidrug resistance protein 1A; Multidrug resistance protein 1B; Multidrug resistance protein 3; multiple drug resistant 1a; P glycoprotein 1; P glycoprotein 3; P-glycoprotein 1; P-glycoprotein 3; P-glycoprotein/multidrug resistance 1; Phospholipid transporter ABCB1

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Gene Aliases: ABC20; ABCB1; Abcb1a; Abcb1b; Abcb4; CD243; CLCS; Evi32; GP170; mdr; mdr-3; MDR1; Mdr1a; Mdr1b; Mdr3; P-GP; Pgp; Pgy-1; Pgy-3; PGY1; Pgy1-1; Pgy3

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UniProt ID: (Human) P08183, (Mouse) P21447, (Mouse) P06795

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Entrez Gene ID: (Human) 5243, (Mouse) 18671, (Rat) 170913, (Mouse) 18669, (Rat) 24646

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Function(s)
transporter activity protein binding ATP binding xenobiotic-transporting ATPase activity ATPase activity, coupled to transmembrane movement of substances nucleotide binding hydrolase activity ATPase activity ATPase activity, coupled drug transmembrane transporter activity
Process(es)
transport drug transmembrane transport establishment of endothelial blood-brain barrier drug transport response to drug transmembrane transport G2/M transition of mitotic cell cycle hormone transport xenobiotic transport daunorubicin transport drug export negative regulation of cell death establishment of blood-brain barrier stem cell proliferation positive regulation of response to drug antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent positive regulation of antigen processing and presentation of peptide antigen via MHC class I response to hypoxia placenta development lactation metabolic process response to ionizing radiation response to organic cyclic compound response to arsenic-containing substance response to steroid hormone cellular response to tumor necrosis factor circadian rhythm response to nutrient levels response to vitamin D cellular response to mycotoxin response to cadmium ion cellular response to antibiotic cellular response to alkaloid cellular response to estradiol stimulus cellular response to organic cyclic compound cellular hyperosmotic salinity response response to dexamethasone cellular response to dexamethasone stimulus response to thyroxine response to L-glutamate
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