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Invitrogen
P-cadherin Polyclonal Antibody
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Product Details
PA5-29790
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the N-terminus region of human P-cadherin. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2547264
Product Specific Information
Recommended positive controls: 293T, B6 mice E15.5,E18.5 embryo tissue.
Predicted reactivity: Mouse (88%), Rat (89%), Bovine (93%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
P-cadherin, also known as Cadherin-3, is a Type 1 cadherin protein that belongs to the cadherin superfamily. Type 1 cadherins are single-pass transmembrane proteins that have 5 extracellular cadherin repeats and an intracellular domain that binds p120-catenin and beta-catenin. Cadherins are calcium-dependent cell-cell adhesion glycoproteins responsible for a range of processes including development, wound healing, cell-cell signaling, cell growth and differentiation. P-cadherin is expressed in human fetal structures, and in adult tissues such as the basal layer of the epidermis, breast, prostate, ovary, cervix, hair follicle, and corneal endothelium. P-cadherin expression has also been reported on embryonic stem cells, and stem cells of the normal mammary gland, and hair follicle. Overexpression of P-cadherin has been associated with poor prognosis in breast, prostate, ovary, colon, and stomach carcinomas. Mutations in CDH3 are associated with congential hypotrichosis with juvenile macular dystrophy.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CADH3; cadherin 3, type 1, P-cadherin (placental); Cadherin-3; calcium-dependent adhesion protein, placental; P-cadherin; Placental cadherin; Placental-cadherin; RPE-specific cadherin
Gene Aliases: AI385538; Cadp; CDH3; CDHP; HJMD; P-cadherin; PCAD
UniProt ID: (Human) P22223, (Mouse) P10287
Entrez Gene ID: (Human) 1001, (Mouse) 12560
retina homeostasis
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
positive regulation of gene expression
positive regulation of keratinocyte proliferation
single organismal cell-cell adhesion
hair cycle process
keratinization
positive regulation of monophenol monooxygenase activity
negative regulation of transforming growth factor beta2 production
positive regulation of insulin-like growth factor receptor signaling pathway
positive regulation of melanin biosynthetic process
negative regulation of catagen
canonical Wnt signaling pathway
regulation of hair cycle by canonical Wnt signaling pathway
positive regulation of melanosome transport
visual perception
adherens junction organization
wound healing
response to drug
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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