Proteintech

P glycoprotein Polyclonal Antibody

P glycoprotein Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 7

P glycoprotein Antibody (22336-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 22336-1-AP ( P glycoprotein antibody at dilution of 1:500 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

P glycoprotein Antibody in Western Blot (WB)

P glycoprotein Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

22336-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 59 publications 59 publications

Immunohistochemistry (IHC)

View 10 publications 10 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 4 publications 4 publications

Flow Cytometry (Flow)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

P glycoprotein Fusion Protein Ag17811 (624-708 aa encoded by BC130424)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.48 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: KLVTMQTAG NEVELENAAD ESKSEIDALE MSSNDSRSSL IRKRSTRRSV RGSQAQDRKL STKEALDESI PPVSFWRIMK LNLTEW (624-708 aa encoded by BC130424)

Target Information

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Liu S,Chen S,Yuan W,Wang H,Chen K,Li D,Li D

Tue Nov 21 00:00:00 UTC 2017

Pleiotrophin promotes chemoresistance to doxorubicin in osteosarcoma by upregulating P-glycoprotein.

Oncotarget

Wu D,Liu L,Yan X,Wang C,Wang Y,Han K,Lin S,Gan Z,Min D

Fri Sep 08 00:00:00 UTC 2017

Pleiotrophin promotes chemoresistance to doxorubicin in osteosarcoma by upregulating P-glycoprotein.

Oncotarget

Wu D,Liu L,Yan X,Wang C,Wang Y,Han K,Lin S,Gan Z,Min D

Fri Sep 08 00:00:00 UTC 2017

Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var.

Genetics and molecular research : GMR

Jiang YQ,Xu XP,Guo QM,Xu XC,Liu QY,An SH,Xu JL,Su F,Tai JB

Fri Sep 02 00:00:00 UTC 2016

Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var.

Genetics and molecular research : GMR

Jiang YQ,Xu XP,Guo QM,Xu XC,Liu QY,An SH,Xu JL,Su F,Tai JB

Fri Sep 02 00:00:00 UTC 2016

Exosomes play an important role in the process of psoralen reverse multidrug resistance of breast cancer.

Journal of experimental & clinical cancer research : CR

Wang X,Xu C,Hua Y,Sun L,Cheng K,Jia Z,Han Y,Dong J,Cui Y,Yang Z

Thu Dec 01 00:00:00 UTC 2016

Exosomes play an important role in the process of psoralen reverse multidrug resistance of breast cancer.

Journal of experimental & clinical cancer research : CR

Wang X,Xu C,Hua Y,Sun L,Cheng K,Jia Z,Han Y,Dong J,Cui Y,Yang Z

Thu Dec 01 00:00:00 UTC 2016

Immunohistochemical analysis of transporters related to clearance of amyloid-β peptides through blood-cerebrospinal fluid barrier in human brain.

Histochemistry and cell biology

Matsumoto K,Chiba Y,Fujihara R,Kubo H,Sakamoto H,Ueno M

Tue Dec 01 00:00:00 UTC 2015

Immunohistochemical analysis of transporters related to clearance of amyloid-β peptides through blood-cerebrospinal fluid barrier in human brain.

Histochemistry and cell biology

Matsumoto K,Chiba Y,Fujihara R,Kubo H,Sakamoto H,Ueno M

Tue Dec 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: ATP-binding cassette sub-family B member 1; ATP-binding cassette sub-family B member 1A; ATP-binding cassette sub-family B member 1B; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 4; ATP-binding cassette, subfamily B, member 1A; ATP-dependent translocase ABCB1; CD243; colchicin sensitivity; doxorubicin resistance; ecotropic viral integration site 32; MDR1A; multi-drug resistance 3; Multidrug resistance protein 1; Multidrug resistance protein 1A; Multidrug resistance protein 1B; Multidrug resistance protein 3; multiple drug resistant 1a; P glycoprotein 1; P glycoprotein 3; P-glycoprotein 1; P-glycoprotein 3; Phospholipid transporter ABCB1

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Gene Aliases: ABC20; ABCB1; Abcb1a; Abcb1b; Abcb4; CD243; CLCS; Evi32; GP170; mdr; mdr-3; MDR1; Mdr1a; Mdr1b; Mdr3; P-GP; Pgp; Pgy-1; Pgy-3; PGY1; Pgy1-1; Pgy3

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UniProt ID: (Human) P08183, (Mouse) P21447, (Mouse) P06795

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Entrez Gene ID: (Human) 5243, (Mouse) 18671, (Mouse) 18669

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Function(s)

transporter activity protein binding ATP binding xenobiotic-transporting ATPase activity ATPase activity, coupled to transmembrane movement of substances nucleotide binding hydrolase activity ATPase activity ATPase activity, coupled drug transmembrane transporter activity

Process(es)

transport drug transmembrane transport establishment of endothelial blood-brain barrier drug transport response to drug transmembrane transport G2/M transition of mitotic cell cycle hormone transport xenobiotic transport daunorubicin transport drug export negative regulation of cell death establishment of blood-brain barrier stem cell proliferation positive regulation of response to drug antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent positive regulation of antigen processing and presentation of peptide antigen via MHC class I

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P glycoprotein Polyclonal Antibody

P glycoprotein Antibody (22336-1-AP) in IHC (P)

Product Details

22336-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

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Type

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Conjugate

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