Proteintech

P-selectin Monoclonal Antibody (3G2C7)

P-selectin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 6

P-selectin Antibody (60322-1-IG) in IHC (P)

Immunohistochemistry of paraffin-embedded human spleen tissue slide using 60322-1-IG ( P-selectin antibody at dilution of 1:50 (under 40x lens).

P-selectin Antibody in Western Blot (WB)

P-selectin Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

60322-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 13 publications 13 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Flow Cytometry (Flow)

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human

Published species

Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

3G2C7

Immunogen

P-selectin Fusion Protein Ag4124 (481-830 aa encoded by BC028067)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.08 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: VCQALQCQD LPVPNEARVN CSHPFGAFRY QSVCSFTCNE GLLLVGASVL QCLATGNWNS VPPECQAIPC TPLLSPQNGT MTCVQPLGSS SYKSTCQFIC DEGYSLSGPE RLDCTRSGRW TDSPPMCEAI KCPELFAPEQ GSLDCSDTRG EFNVGSTCHF SCNNGFKLEG PNNVECTTSG RWSATPPTCK GIASLPTPGV QCPALTTPGQ GTMYCRHHPG TFGFNTTCYF GCNAGFTLIG DSTLSCRPSG QWTAVTPACR AVKCSELHVN KPIAMNCSNL WGNFSYGSIC SFHCLEGQLL NGSAQTACQE NGHWSTTVPT CQDDGKCPLN PHSHLGTYGV FTNAAFDPSP (481-830 aa encoded by BC028067)

Target Information

P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins that regulate cell rolling. P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets. From there, it can be rapidly brought to the cell surface after exposure to thrombin, histamine, complement 5a, Ca21 ionophores, or adenosine diphosphate. P-selectin protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. P-selectin plays an important role in adhesive processes between leucocytes and endothelial cells, and is a calcium dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens found on neutrophils and monocytes. P-selectin is constitutively expressed in inflammation and contributes to atherogenesis, thrombosis and tissue destruction. Clinically, P-selectin is used to distinguish heparin induced thrombocytopenia with and without thrombosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Curcumin-Loaded Platelet Membrane Bioinspired Chitosan-Modified Liposome for Effective Cancer Therapy.

Pharmaceutics

Wan S,Fan Q,Wu Y,Zhang J,Qiao G,Jiang N,Yang J,Liu Y,Li J,Chiampanichayakul S,Tima S,Tong F,Anuchapreeda S,Wu J

Mon Feb 13 00:00:00 UTC 2023

Analysis of CRSsNP Proteome Using a Highly Multiplexed Approach in Nasal Mucus.

American journal of rhinology & allergy

Pesold VV,Wendler O,Morgenthaler L,Gröhn F,Mueller SK

Mon May 01 00:00:00 UTC 2023

Remodeling Collagen Microenvironment in Liver Using a Biomimetic Nano-Regulator for Reversal of Liver Fibrosis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Liang Y,Wang J,Xu C,Han W,Wu S,Wu Y,Zhang J,Liu J,Zhang Z,Shi J,Zhang K

Thu Jun 01 00:00:00 UTC 2023

Humic Acids Inhibit Platelet Activation to Reduce Venous Thromboembolism in Mice.

Evidence-based complementary and alternative medicine : eCAM

Lan HT,Zheng YT,Tong ZJ,Zhang C,Cong XY,Wang ZH

Wed Jan 11 00:00:00 UTC 2023

Platelet-Membrane-Encapsulated Carvedilol with Improved Targeting Ability for Relieving Myocardial Ischemia-Reperfusion Injury.

Membranes

Zhou T,Yang X,Wang T,Xu M,Huang Z,Yu R,Jiang Y,Zhou Y,Shi J

Fri Jun 10 00:00:00 UTC 2022

MAC mediates mammary duct epithelial cell injury in plasma cell mastitis and granulomatous mastitis.

International immunopharmacology

Zhang HJ,Ding PP,Zhang XS,Wang XC,Sun DW,Bu QA,Li XQ

Thu Dec 01 00:00:00 UTC 2022

Effects of Momordica charantia exosomes on platelet activation, adhesion, and aggregation.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis

Zhang J,Wang W,Liu T,Wang Y,Wei X,Qi S,Gu B

Sat Oct 01 00:00:00 UTC 2022

Bioinspired Platelet-like Nanovector for Enhancing Cancer Therapy via P-Selectin Targeting.

Pharmaceutics

Wan S,Wu Y,Fan Q,Yang G,Hu H,Tima S,Chiampanichayakul S,Anuchapreeda S,Wu J

Sat Nov 26 00:00:00 UTC 2022

The mechanism underlying ICAM-1 and E-selectin-mediated hypertriglyceridemic pancreatitis-associated lung injury.

Molecular immunology

Yu R,Hou C,Peng Y,Zhu X,Shi C,Huang D,Miao Y,Li Q

Thu Dec 01 00:00:00 UTC 2022

The mechanism underlying ICAM-1 and E-selectin-mediated hypertriglyceridemic pancreatitis-associated lung injury.

Molecular immunology

Yu R,Hou C,Peng Y,Zhu X,Shi C,Huang D,Miao Y,Li Q

Thu Dec 01 00:00:00 UTC 2022

Rescuing ischemic stroke by biomimetic nanovesicles through accelerated thrombolysis and sequential ischemia-reperfusion protection.

Acta biomaterialia

Yu W,Yin N,Yang Y,Xuan C,Liu X,Liu W,Zhang Z,Zhang K,Liu J,Shi J

Tue Mar 01 00:00:00 UTC 2022

CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis.

Biological research

Zhang X,Lu J,Zhang Q,Luo Q,Liu B

Tue Mar 23 00:00:00 UTC 2021

Association of Pericyte Loss With Microthrombosis After Subarachnoid Hemorrhage in ApoE-Deficient Mice.

Frontiers in neurology

Pang J,Wu Y,Peng J,Yang P,Chen L,Jiang Y

Wed Sep 29 00:00:00 UTC 2021

Association of Pericyte Loss With Microthrombosis After Subarachnoid Hemorrhage in ApoE-Deficient Mice.

Frontiers in neurology

Pang J,Wu Y,Peng J,Yang P,Chen L,Jiang Y

Wed Sep 29 00:00:00 UTC 2021

An Essential NRP1-Mediated Role for Tagln2 in Gastric Cancer Angiogenesis.

Frontiers in oncology

Jin H,Zheng W,Hou J,Peng H,Zhuo H

Tue Jun 22 00:00:00 UTC 2021

Platelet Membranes Coated Gold Nanocages for Tumor Targeted Drug Delivery and Amplificated Low-Dose Radiotherapy.

Frontiers in oncology

Chen M,Wang P,Jiang D,Bao Z,Quan H

Wed Dec 15 00:00:00 UTC 2021

Generation and characterization of cardiac valve endothelial-like cells from human pluripotent stem cells.

Communications biology

Cheng L,Xie M,Qiao W,Song Y,Zhang Y,Geng Y,Xu W,Wang L,Wang Z,Huang K,Dong N,Sun Y

Mon Sep 06 00:00:00 UTC 2021

Nano-Platelets as an Oxygen Regulator for Augmenting Starvation Therapy Against Hypoxic Tumor.

Frontiers in bioengineering and biotechnology

Huang C,Zhu C,Chen J,Huang K,Li F,Ding S,Xia L,Jiang W,Li Y

Tue Oct 06 00:00:00 UTC 2020

Low molecular weight fucoidan modulates P-selectin and alleviates diabetic nephropathy.

International journal of biological macromolecules

Xu Y,Zhang Q,Luo D,Wang J,Duan D

Sat Oct 01 00:00:00 UTC 2016

Low molecular weight fucoidan modulates P-selectin and alleviates diabetic nephropathy.

International journal of biological macromolecules

Xu Y,Zhang Q,Luo D,Wang J,Duan D

Sat Oct 01 00:00:00 UTC 2016

Low molecular weight fucoidan modulates P-selectin and alleviates diabetic nephropathy.

International journal of biological macromolecules

Xu Y,Zhang Q,Luo D,Wang J,Duan D

Sat Oct 01 00:00:00 UTC 2016

Low molecular weight fucoidan modulates P-selectin and alleviates diabetic nephropathy.

International journal of biological macromolecules

Xu Y,Zhang Q,Luo D,Wang J,Duan D

Sat Oct 01 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: CD62 antigen-like family member P; CD62P; FLJ45155; GMP-140; Granule membrane protein 140; granule membrane protein 140kDa; granulocyte membrane protein; LECAM3; Leukocyte-endothelial cell adhesion molecule 3; P-selectin; PADGEM; Platelet activation dependent granule-external membrane protein; platelet alpha-granule membrane protein; RP1-86F14.2; selectin P (granule membrane protein 140kDa, antigen CD62)

View more View less

Gene Aliases: CD62; CD62P; GMP140; GMRP; GRMP; LECAM3; PADGEM; PSEL; SELP

View more View less

UniProt ID: (Human) P16109

View more View less

Entrez Gene ID: (Human) 6403

View more View less

Function(s)

lipopolysaccharide binding glycoprotein binding protein binding heparin binding sialic acid binding fucose binding glycosphingolipid binding calcium-dependent protein binding oligosaccharide binding

Process(es)

platelet degranulation positive regulation of leukocyte migration regulation of cellular extravasation inflammatory response cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion positive regulation of platelet activation positive regulation of phosphatidylinositol 3-kinase signaling response to organic cyclic compound response to lipopolysaccharide regulation of integrin activation calcium-mediated signaling using intracellular calcium source positive regulation of cell adhesion defense response to Gram-negative bacterium leukocyte migration leukocyte tethering or rolling

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

P-selectin Monoclonal Antibody (3G2C7)

P-selectin Antibody (60322-1-IG) in IHC (P)

Product Details

60322-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!