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P2RX2 Polyclonal Antibody
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Product Details
OSP00026W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from mouse P2RX2 conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: P2RX2.
Target Information
P2rx2 are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains. P2rx2 functions as a ligand-gated ion channel and binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for P2rx2. P2rx2 is involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, P2rx2 regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. P2rx2 also mediates synaptic transmission between neurons and from neurons to smooth muscle. Diseases associated with P2RX2 include Deafness, Autosomal Dominant 41 and Dfna41 Nonsyndromic Hearing Loss And Deafness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATP receptor; MGC129601; P2X purinoceptor 2; P2X Receptor, subunit 2; P2X2; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 2; purinergic receptor P2X, ligand-gated ion channel, 2
Gene Aliases: DFNA41; P2RX2; P2X2; P2X2a
UniProt ID: (Human) Q9UBL9, (Rat) P49653, (Mouse) Q8K3P1
Entrez Gene ID: (Human) 22953, (Rat) 114115, (Mouse) 231602
purinergic nucleotide receptor activity
extracellular ATP-gated cation channel activity
ATP binding
ligand-gated ion channel activity
identical protein binding
ion channel activity
copper ion binding
protein binding
drug binding
zinc ion binding
nickel cation binding
phosphatidylinositol binding
mercury ion binding
cadmium ion binding
cobalt ion binding
response to hypoxia
detection of hypoxic conditions in blood by carotid body chemoreceptor signaling
cation transport
chemical synaptic transmission
neuromuscular synaptic transmission
neuromuscular junction development
sensory perception of sound
response to carbohydrate
response to organic substance
urinary bladder smooth muscle contraction
neuronal action potential
peristalsis
response to ATP
ion transmembrane transport
purinergic nucleotide receptor signaling pathway
behavioral response to pain
skeletal muscle fiber development
sensory perception of taste
protein homooligomerization
protein heterooligomerization
cation transmembrane transport
blood coagulation
positive regulation of calcium ion transport into cytosol
positive regulation of calcium-mediated signaling
transport
ion transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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