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Product Details
OSP00094W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from the cytoplasmic domain of human P2X3 (P2RX3, P2X purinoceptor 3, ATP receptor) conjugated to an immunogenic carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide shares 85% identity with rat and mouse sequence.
Specificity of this antibody: P2RX3.
Target Information
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATP receptor; MGC129956; P2X purinoceptor 3; p2X receptor 3; P2X receptor, subunit 3; P2X3; p2X3 purinoceptor; p2xr3; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 3; purinergic receptor P2X, ligand-gated ion channel, 3; purinergic receptor P2X3; purinoceptor P2X3
Gene Aliases: P2RX3; P2X3
UniProt ID: (Human) P56373
Entrez Gene ID: (Human) 5024
response to hypoxia
transport
signal transduction
neuromuscular synaptic transmission
blood coagulation
response to heat
response to cold
response to mechanical stimulus
response to carbohydrate
positive regulation of calcium ion transport into cytosol
urinary bladder smooth muscle contraction
neuronal action potential
peristalsis
response to ATP
purinergic nucleotide receptor signaling pathway
regulation of synaptic plasticity
positive regulation of calcium-mediated signaling
sensory perception of taste
protein homooligomerization
behavioral response to formalin induced pain
cation transmembrane transport
positive regulation of sensory perception of pain
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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