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Alomone Labs, LTD
P2X3 Polyclonal Antibody
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FIGURE: 1 / 3
P2X3 Antibody (APR-016-GP200UL) in IHC (F)
Expression of P2X3 in mouse paraventricular nucleus of the hypothalamus (PVN). Immunohistochemical staining of perfusion-fixed frozen mouse brain sections using Guinea pig Anti-P2X3 Antibody (#APR-016-GP), (1:200), followed by goat Anti-guinea pig-AlexaFluor-594. A. P2X3 immunoreactivity (red) appears in neuronal profiles (arrows). B. Pre-incubation of the Antibody with P2X3 Blocking Peptide (BLP-PR016), su... View More
Product Details
APR-016-GP200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Guinea pig
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)VEKQSTDSGAYSIGH, corresponding to amino acid residues 383-397 of rat P2X3 receptor, Intracellular, C-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
Target Information
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP receptor; MGC129956; P2X purinoceptor 3; p2X receptor 3; P2X receptor, subunit 3; P2X3; p2X3 purinoceptor; p2xr3; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 3; purinergic receptor P2X, ligand-gated ion channel, 3; purinergic receptor P2X3; purinoceptor P2X3
Gene Aliases: 4930513E20Rik; P2RX3; P2X3
UniProt ID: (Human) P56373, (Rat) P49654, (Mouse) Q3UR32
Entrez Gene ID: (Human) 5024, (Rat) 81739, (Mouse) 228139
response to hypoxia
ion transport
cation transport
chemical synaptic transmission
neuromuscular synaptic transmission
response to temperature stimulus
response to heat
response to cold
response to mechanical stimulus
response to carbohydrate
response to organic substance
urinary bladder smooth muscle contraction
neuronal action potential
peristalsis
response to ATP
purinergic nucleotide receptor signaling pathway
regulation of synaptic plasticity
behavioral response to pain
sensory perception of taste
protein homooligomerization
cation transmembrane transport
transport
signal transduction
blood coagulation
positive regulation of calcium ion transport into cytosol
positive regulation of calcium-mediated signaling
behavioral response to formalin induced pain
positive regulation of sensory perception of pain
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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