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P2X5 Receptor (extracellular) Antibody (APR-027-200UL) in WB
Western blot analysis of rat heart (lanes 1 and 3) and mouse heart (lanes 2 and 4): - 1,2. Anti-P2X5 Receptor (extracellular) Antibody (#APR-027), (1:400).3,4. Anti-P2X5 Receptor (extracellular) Antibody , preincubated with P2X5 Receptor (extracellular) Blocking Peptide (#BLP-PR027).
Product Details
APR-027-200UL
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)HRSHTRLAEMKYE, corresponding to amino acid residues 299-311 of rat P2X5 receptor, Extracellular loop
Conjugate
Form
Lyophilized
Concentration
0.85 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
Target Information
Mmgt2 mediates Mg(2+) transport and may provide regulated pathways for Mg(2+) transport in the Golgi and post-Golgi organelles of epithelium-derived cells. Magnesium is an essential metal, but few selective transporters have been identified. The two separate gene products, Mmgt1 and Mmgt2, comprise the family that we have termed membrane Mg(2+) transporters (MMgTs), and the proteins reside in the membrane and mediate Mg(2+) transport. The transport of Mg(2+) is saturable and studies have identified that Mmgt2 fusion proteins reside in the Golgi complex and post-Golgi vesicles, including the early endosomes in COS-7 cells transfected with the respective tagged constructs. Among related pathways for Mmgt2 are transport and binding events, in particular, transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP receptor; Membrane magnesium transporter 2; membrane magnesium transporter 2 {ECO:0000250|UniProtKB:Q8R3L0}; MGC47755; mmgt2; mmgt2 {ECO:0000250|UniProtKB:Q8R3L0}; P2X purinoceptor 5; P2X5; Purinergic receptor; purinergic receptor P2X5-2
Gene Aliases: AI852046; Mmgt2; P2rx5; P2X5; RGD1311260
UniProt ID: (Rat) Q6P719, (Mouse) Q8R3L0, (Mouse) Q91VE2, (Rat) P51578
Entrez Gene ID: (Rat) 303211, (Mouse) 216829, (Mouse) 94045, (Rat) 113995
magnesium ion transmembrane transporter activity
copper ion transmembrane transporter activity
manganese ion transmembrane transporter activity
cobalt ion transmembrane transporter activity
nickel cation transmembrane transporter activity
inorganic cation transmembrane transporter activity
purinergic nucleotide receptor activity
extracellular ATP-gated cation channel activity
ATP binding
GTP binding
drug binding
zinc ion binding
cell surface receptor signaling pathway
neuronal action potential
purinergic nucleotide receptor signaling pathway
regulation of skeletal muscle tissue regeneration
protein homooligomerization
cation transmembrane transport
mitophagy in response to mitochondrial depolarization
magnesium ion transport
cation transport
skeletal muscle tissue growth
transport
cobalt ion transport
copper ion transport
manganese ion transport
nickel cation transport
copper ion transmembrane transport
nickel cation transmembrane transport
manganese ion transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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