Invitrogen

P2X7 Monoclonal Antibody (Hano43)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-28184

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-

Flow Cytometry (Flow)

Assay-dependent
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rat / IgG2b

Class

Monoclonal

Type

Antibody

Clone

Hano43

Immunogen

A P2X7-expression construct and a final boost with P2X7-transfected HEK cells

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2745159

Product Specific Information

Rat anti Mouse P2X7 antibody, clone Hano43 recognizes the P2X purinoceptor 7, also known as P2X7. The P2X7 ATP receptor has a distinctive long C-terminal tail with multiple potential protein and lipid interaction motifs and is highly polymorphic.

Target Information

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay criteria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATP receptor; MGC20089; P2X purinoceptor 7; p2X receptor 7; P2X7; P2X7 purinoceptor; P2X7 receptor; P2Z; P2Z receptor; Purinergic receptor

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Gene Aliases: AI467586; P2rx7; P2X(7); P2x7; P2X7R

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UniProt ID: (Mouse) Q9Z1M0

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Entrez Gene ID: (Mouse) 18439

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Function(s)
lipopolysaccharide binding purinergic nucleotide receptor activity receptor activity extracellular ATP-gated cation channel activity ion channel activity protein binding ATP binding channel activity
Process(es)
activation of MAPK activity cell morphogenesis phagolysosome assembly positive regulation of T cell mediated cytotoxicity positive regulation of protein phosphorylation protein phosphorylation membrane protein ectodomain proteolysis phospholipid transfer to membrane transport ion transport cation transport calcium ion transport cell volume homeostasis membrane budding inflammatory response mitochondrion organization plasma membrane organization response to mechanical stimulus response to bacterium response to organic substance response to zinc ion gene expression positive regulation of calcium ion transport into cytosol positive regulation of gene expression programmed cell death positive regulation of glutamate secretion positive regulation of gamma-aminobutyric acid secretion response to organic cyclic compound synaptic vesicle exocytosis protein processing phospholipid scrambling sensory perception of pain cytolysis positive regulation of bone mineralization cellular response to extracellular stimulus bleb assembly positive regulation of prostaglandin secretion response to lipopolysaccharide positive regulation of interleukin-1 beta production positive regulation of interleukin-6 production collagen metabolic process response to ATP response to fluid shear stress positive regulation of ion transmembrane transport purinergic nucleotide receptor signaling pathway T cell proliferation response to drug T cell homeostasis positive regulation of apoptotic process positive regulation of catalytic activity NAD transport negative regulation of MAPK cascade positive regulation of MAPK cascade multicellular organismal protein catabolic process phospholipid translocation positive regulation of ossification negative regulation of bone resorption negative regulation of cell volume positive regulation of glycolytic process ceramide biosynthetic process pore complex assembly skeletal system morphogenesis homeostasis of number of cells within a tissue positive regulation of protein secretion positive regulation of cytokine secretion positive regulation of interleukin-1 alpha secretion positive regulation of interleukin-1 beta secretion defense response to Gram-positive bacterium release of sequestered calcium ion into cytosol protein oligomerization response to calcium ion response to electrical stimulus membrane depolarization positive regulation of mitochondrial depolarization positive regulation of lymphocyte apoptotic process cellular response to dsRNA cellular response to organic cyclic compound reactive oxygen species metabolic process extrinsic apoptotic signaling pathway cation transmembrane transport positive regulation of bleb assembly
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