Alomone Labs, LTD

P2Y1 Receptor (extracellular) Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

APR-021-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (IHC)

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-

Flow Cytometry (Flow)

5 µg/1x10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SDEYLRSYFIYSMC, corresponding to amino acid residues 207-220 of human P2RY1, 2nd extracellular loop
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).

Target Information

P2Y1 is a Purinergic Receptor that causes a change in platelet shape and potentially leads to platelet aggregation by binding ADP, which results in the mobilization of intracellular calcium ions via activation of phospholipase C. This receptor also mediates the release of the relaxing factor nitric oxide and may be involved in the modulation of neuronal signal transmission. P2Y1 has been reported to be expressed in tissues throughout the body, particularly brain. ESTs have been isolated from human embryo, lung, and placenta libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ADP receptor; ATP receptor; P2 purinoceptor subtype Y1; P2 purinoreceptor subclass 2Y; P2Y ATP receptor 1; P2Y purinoceptor 1; p2y-1-r; P2Y1; P2Y1 receptor; p2y1r; platelet ADP receptor; Purinergic receptor; purinergic receptor P2Y, G-protein coupled, 1; Purinoceptor p2y1; Purinoceptor p2yr1

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Gene Aliases: P2RY1; P2y; P2Y1

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UniProt ID: (Human) P47900, (Rat) P49651, (Mouse) P49650

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Entrez Gene ID: (Human) 5028, (Rat) 25265, (Mouse) 18441

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Function(s)
receptor activity protein binding ATP binding A1 adenosine receptor binding ADP binding G-protein coupled purinergic nucleotide receptor activity ATP-activated adenosine receptor activity ADP-activated adenosine receptor activity protein heterodimerization activity scaffold protein binding signal transducer activity G-protein coupled receptor activity
Process(es)
positive regulation of protein phosphorylation adenosine receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration aging glial cell migration response to mechanical stimulus regulation of receptor activity negative regulation of norepinephrine secretion sensory perception of pain signal transduction involved in regulation of gene expression platelet activation positive regulation of inositol trisphosphate biosynthetic process G-protein coupled purinergic nucleotide receptor signaling pathway wound healing regulation of vasodilation eating behavior positive regulation of ion transport positive regulation of transcription from RNA polymerase II promoter positive regulation of hormone secretion negative regulation of binding positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway positive regulation of penile erection positive regulation of ERK1 and ERK2 cascade response to growth factor cellular response to organic cyclic compound protein localization to plasma membrane relaxation of muscle cell surface receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway signal transduction
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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