Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
PABP Monoclonal Antibody (10E10)
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
MA5-46551
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Hamster,
Human,
Rabbit,
Xenopus
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
10E10
Immunogen
Human recombinant PABP expressed from its 1.85 kbp cDNA, NcoI to SspI
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2937623
Product Specific Information
Western blot detects a band of approximately 70 kDa (predicted molecular weight: 71 kDa).
Target Information
The poly(A)-binding protein (PABP), which is found complexed to the 3-prime poly(A) tail of eukaryotic mRNA, is required for poly(A) shortening and translation initiation. In humans, the PABPs comprise a small nuclear isoform and a conserved gene family that displays at least 3 functional proteins: PABP1 (PABPC1), inducible PABP (iPABP, or PABPC4), and PABP3 (PABPC3). In addition, there are at least 4 pseudogenes, PABPCP1 to PABPCP4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: cytoplasmic poly(A)-binding protein 1-A; PABP-1; PABP-1-A; PABP-A; poly A binding protein, cytoplasmic 4; poly(A) binding protein, cytoplasmic 1; poly(A) binding protein, cytoplasmic 1 L homeolog; poly(A) binding protein, cytoplasmic 2; poly(A)-binding protein 1-A; Polyadenylate-binding protein 1; xPABP1-A
Gene Aliases: I79_019955; PAB1; PABP; PABP1; PABPC1; pabpc1-a; pabpc1-b; pabpc1.L; PABPC2; PABPL1; RCJMB04_7l20; XELAEV_18033915mg
UniProt ID: (Human) P11940
Entrez Gene ID: (Rabbit) 100342434, (Human) 26986, (Chicken) 430997, (Chinese hamster) 100757538, (Xenopus) 379896
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
nuclear-transcribed mRNA poly(A) tail shortening
mRNA splicing, via spliceosome
mRNA polyadenylation
translational initiation
gene silencing by RNA
regulation of mRNA stability
positive regulation of viral genome replication
positive regulation of translation
mRNA stabilization
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support