Proteintech

PABPC1/PABP Polyclonal Antibody

PABPC1/PABP Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 17

PABPC1/PABP Antibody (10970-1-AP) in ICC/IF

Immunofluorescent analysis of MCF-7 cells, using PABPC1 antibody 10970-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

PABPC1/PABP Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PABPC1/PABP Antibody in Western Blot (WB)

PABPC1/PABP Antibody in Flow Cytometry (Flow)

PABPC1/PABP Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10970-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 12 publications 12 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 2 publications 2 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PABPC1,PABP Fusion Protein Ag1422 (287-636 aa encoded by BC015958)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: RITRYQGVN LYVKNLDDGI DDERLRKEFS PFGTITSAKV MMEGGRSKGF GFVCFSSPEE ATKAVTEMNG RIVATKPLYV ALAQRKEERQ AHLTNQYMQR MASVRAVPNP VINPYQPAPP SGYFMAAIPQ TQNRAAYYPP SQIAQLRPSP RWTAQGARPH PFQNMPGAIR PAAPRPPFST MRPASSQVPR VMSTQRVANT STQTMGPRPA AAAAAATPAV RTVPQYKYAA GVRNPQQHLN AQPQVTMQQP AVHVQGQEPL TASMLASAPP QEQKQMLGER LFPLIQAMHP TLAGKITGML LEIDNSELLH MLESPESLRS KVDEAVAVLQ AHQAKEAAQK AVNSATGVPT V (287-636 aa encoded by BC015958)

Target Information

The poly(A)-binding protein (PABP), which is found complexed to the 3-prime poly(A) tail of eukaryotic mRNA, is required for poly(A) shortening and translation initiation. In humans, the PABPs comprise a small nuclear isoform and a conserved gene family that displays at least 3 functional proteins: PABP1 (PABPC1), inducible PABP (iPABP, or PABPC4), and PABP3 (PABPC3). In addition, there are at least 4 pseudogenes, PABPCP1 to PABPCP4.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

LncRNA BC promotes lung adenocarcinoma progression by modulating IMPAD1 alternative splicing.

Clinical and translational medicine

Chen QW,Cai QQ,Yang Y,Dong S,Liu YY,Chen ZY,Kang CL,Qi B,Dong YW,Wu W,Zhuang LP,Shen YH,Meng ZQ,Wu XZ

Sun Jan 01 00:00:00 UTC 2023

T-2 toxin and deoxynivalenol (DON) exert distinct effects on stress granule formation depending on altered activity of SIRT1.

Ecotoxicology and environmental safety

Jiang T,Qi X,Lin R,Jiang J,Wen J,Deng Y

Sat Jul 01 00:00:00 UTC 2023

TIAR and FMRP shape pro-survival nascent proteome of leukemia cells in the bone marrow microenvironment.

iScience

Wolczyk M,Serwa R,Kominek A,Klejman A,Milek J,Chwałek M,Turos-Korgul L,Charzyńska A,Dabrowski M,Dziembowska M,Skorski T,Piwocka K,Podszywalow-Bartnicka P

Fri Apr 21 00:00:00 UTC 2023

LncRNA WDR11-AS1 Promotes Extracellular Matrix Synthesis in Osteoarthritis by Directly Interacting with RNA-Binding Protein PABPC1 to Stabilize SOX9 Expression.

International journal of molecular sciences

Huang H,Yan J,Lan X,Guo Y,Sun M,Zhao Y,Zhang F,Sun J,Lu S

Tue Jan 03 00:00:00 UTC 2023

LncRNA WDR11-AS1 Promotes Extracellular Matrix Synthesis in Osteoarthritis by Directly Interacting with RNA-Binding Protein PABPC1 to Stabilize SOX9 Expression.

International journal of molecular sciences

Huang H,Yan J,Lan X,Guo Y,Sun M,Zhao Y,Zhang F,Sun J,Lu S

Tue Jan 03 00:00:00 UTC 2023

CircPTK2/PABPC1/SETDB1 axis promotes EMT-mediated tumor metastasis and gemcitabine resistance in bladder cancer.

Cancer letters

Meng X,Xiao W,Sun J,Li W,Yuan H,Yu T,Zhang X,Dong W

Wed Feb 01 00:00:00 UTC 2023

YTHDF3 modulates hematopoietic stem cells by recognizing RNA m⁶A modification on Ccnd1.

Haematologica

Zhang X,Cong T,Wei L,Zhong B,Wang X,Sun J,Wang S,Xu MM,Zhu P,Jiang H,Wang J

Sat Oct 01 00:00:00 UTC 2022

YTHDF3 modulates hematopoietic stem cells by recognizing RNA m⁶A modification on Ccnd1.

Haematologica

Zhang X,Cong T,Wei L,Zhong B,Wang X,Sun J,Wang S,Xu MM,Zhu P,Jiang H,Wang J

Sat Oct 01 00:00:00 UTC 2022

The deubiquitinating enzyme STAMBP is a newly discovered driver of triple-negative breast cancer progression that maintains RAI14 protein stability.

Experimental & molecular medicine

Yang Q,Yan D,Zou C,Xue Q,Lin S,Huang Q,Li X,Tang D,Chen X,Liu J

Tue Nov 01 00:00:00 UTC 2022

Viral proteases activate the CARD8 inflammasome in the human cardiovascular system.

The Journal of experimental medicine

Nadkarni R,Chu WC,Lee CQE,Mohamud Y,Yap L,Toh GA,Beh S,Lim R,Fan YM,Zhang YL,Robinson K,Tryggvason K,Luo H,Zhong F,Ho L

Mon Oct 03 00:00:00 UTC 2022

E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non-small cell lung cancer.

The Journal of experimental medicine

Li K,Zheng X,Tang H,Zang YS,Zeng C,Liu X,Shen Y,Pang Y,Wang S,Xie F,Lu X,Luo Y,Li Z,Bi W,Jia X,Huang T,Wei R,Huang K,Chen Z,Zhu Q,He Y,Zhang M,Gu Z,Xiao Y,Zhang X,Fletcher JA,Wang Y

Mon Aug 02 00:00:00 UTC 2021

NcPuf1 Is a Key Virulence Factor in Neospora caninum.

Pathogens (Basel, Switzerland)

Wang C,Yang C,Liu J,Liu Q

Wed Dec 02 00:00:00 UTC 2020

Enhancer-Driven lncRNA BDNF-AS Induces Endocrine Resistance and Malignant Progression of Breast Cancer through the RNH1/TRIM21/mTOR Cascade.

Cell reports

Lin X,Dinglin X,Cao S,Zheng S,Wu C,Chen W,Li Q,Hu Q,Zheng F,Wu Z,Lin DC,Yao Y,Xu X,Xie Z,Liu Q,Yao H,Hu H

Tue Jun 09 00:00:00 UTC 2020

An oncopeptide regulates m⁶A recognition by the m⁶A reader IGF2BP1 and tumorigenesis.

Nature communications

Zhu S,Wang JZ,Chen D,He YT,Meng N,Chen M,Lu RX,Chen XH,Zhang XL,Yan GR

Fri Apr 03 00:00:00 UTC 2020

Purification of cross-linked RNA-protein complexes by phenol-toluol extraction.

Nature communications

Urdaneta EC,Vieira-Vieira CH,Hick T,Wessels HH,Figini D,Moschall R,Medenbach J,Ohler U,Granneman S,Selbach M,Beckmann BM

Fri Mar 01 00:00:00 UTC 2019

An atlas of bloodstream-accessible bone marrow proteins for site-directed therapy of acute myeloid leukemia.

Leukemia

Angenendt L,Reuter S,Kentrup D,Benk AS,Neumann F,Hüve J,Martens AC,Schwöppe C,Kessler T,Schmidt LH,Sauer T,Brand C,Mikesch JH,Lenz G,Mesters RM,Müller-Tidow C,Hartmann W,Wardelmann E,Neri D,Berdel WE,Roesli C,Schliemann C

Thu Feb 01 00:00:00 UTC 2018

TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteins.

Scientific reports

Prpar Mihevc S,Baralle M,Buratti E,Rogelj B

Mon Sep 26 00:00:00 UTC 2016

TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteins.

Scientific reports

Prpar Mihevc S,Baralle M,Buratti E,Rogelj B

Mon Sep 26 00:00:00 UTC 2016

TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteins.

Scientific reports

Prpar Mihevc S,Baralle M,Buratti E,Rogelj B

Mon Sep 26 00:00:00 UTC 2016

TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteins.

Scientific reports

Prpar Mihevc S,Baralle M,Buratti E,Rogelj B

Mon Sep 26 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: PABP 1; PABP-1; poly A binding protein 1; poly(A) binding protein, cytoplasmic 1; poly(A) binding protein, cytoplasmic 2; poly(A)-binding protein 1; Polyadenylate-binding protein 1

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Gene Aliases: ePAB; PAB1; PABP; PABP1; PABPC1; PABPC2; PabpI; PABPL1

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UniProt ID: (Human) P11940, (Rat) Q9EPH8, (Mouse) P29341

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Entrez Gene ID: (Human) 26986, (Rat) 171350, (Mouse) 18458

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Function(s)

nucleotide binding protein binding protein C-terminus binding poly(A) binding poly(U) RNA binding translation activator activity poly(A) RNA binding mRNA binding nucleic acid binding RNA binding

Process(es)

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay mRNA processing RNA splicing gene silencing by RNA positive regulation of nuclear-transcribed mRNA poly(A) tail shortening positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nuclear-transcribed mRNA poly(A) tail shortening mRNA splicing, via spliceosome mRNA polyadenylation translational initiation regulation of mRNA stability positive regulation of viral genome replication positive regulation of translation mRNA stabilization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PABPC1/PABP Polyclonal Antibody

PABPC1/PABP Antibody (10970-1-AP) in ICC/IF

Product Details

10970-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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