Bioss

PACAP-38 Polyclonal Antibody

View all (2) PACAP-38 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

BS-0200R

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human PACAP-38, amino acids 31-38.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: adenylate cyclase activating polypeptide 1 (pituitary); PACAP; pituitary adenylate cyclase activating polypeptide; pituitary adenylate cyclase activating polypeptide 1; Pituitary adenylate cyclase-activating polypeptide; pituitary adenylate cyclase-activating polypeptide precursor (Pacap); prepro-PACAP

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Gene Aliases: ADCYAP1; PACAP

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UniProt ID: (Human) P18509, (Rat) P13589, (Mouse) O70176

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Entrez Gene ID: (Human) 116, (Rat) 24166, (Mouse) 11516

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Function(s)
receptor signaling protein activity receptor binding neuropeptide hormone activity protein binding pituitary adenylate cyclase activating polypeptide activity pituitary adenylate cyclase-activating polypeptide receptor binding peptide hormone receptor binding hormone activity
Process(es)
ovarian follicle development behavioral fear response histamine secretion negative regulation of acute inflammatory response to antigenic stimulus negative regulation of acute inflammatory response to non-antigenic stimulus positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway regulation of G-protein coupled receptor protein signaling pathway positive regulation of cell proliferation positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway positive regulation of gene expression negative regulation of muscle cell apoptotic process positive regulation of neuron projection development sensory perception of pain cAMP-mediated signaling pituitary gland development positive regulation of cAMP biosynthetic process neuron projection development positive regulation of interleukin-6 production regulation of protein localization negative regulation of GTPase activity intracellular signal transduction response to starvation negative regulation of potassium ion transport response to ethanol negative regulation of cell cycle positive regulation of protein kinase activity positive regulation of vasodilation positive regulation of transcription from RNA polymerase II promoter ATP metabolic process positive regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential positive regulation of growth hormone secretion negative regulation of glial cell proliferation positive regulation of ERK1 and ERK2 cascade regulation of oligodendrocyte progenitor proliferation cellular response to glucocorticoid stimulus positive regulation of somatostatin secretion activation of adenylate cyclase activity nervous system development positive regulation of GTPase activity positive regulation of chemokine (C-C motif) ligand 5 production cell-cell signaling female pregnancy
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