Invitrogen

PACAP-38 Polyclonal Antibody

View all (2) PACAP-38 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-143860

Applications
Tested Dilution
Publications

Western Blot (WB)

0.25-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

2-5 µg/mL
-

Flow Cytometry (Flow)

1-3 µg/1x10^6 cells
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence of human PACAP-38/ADCYAP1 (QMAVKKYLAAVLGKRYKQRVK).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3075074

Product Specific Information

Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

Positive Control - WB: human HEL whole cell. IHC: human lung cancer tissue. Flow: HEL cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Information

Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: adenylate cyclase activating polypeptide 1 (pituitary); PACAP; pituitary adenylate cyclase activating polypeptide; Pituitary adenylate cyclase-activating polypeptide; prepro-PACAP

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Gene Aliases: ADCYAP1; PACAP

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UniProt ID: (Human) P18509

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Entrez Gene ID: (Human) 116

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Function(s)
receptor signaling protein activity receptor binding neuropeptide hormone activity protein binding pituitary adenylate cyclase activating polypeptide activity pituitary adenylate cyclase-activating polypeptide receptor binding peptide hormone receptor binding
Process(es)
ovarian follicle development behavioral fear response histamine secretion negative regulation of acute inflammatory response to antigenic stimulus negative regulation of acute inflammatory response to non-antigenic stimulus activation of adenylate cyclase activity positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway cell-cell signaling female pregnancy regulation of G-protein coupled receptor protein signaling pathway positive regulation of cell proliferation positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway negative regulation of muscle cell apoptotic process positive regulation of neuron projection development sensory perception of pain cAMP-mediated signaling pituitary gland development neuron projection development positive regulation of interleukin-6 production regulation of protein localization negative regulation of GTPase activity response to starvation negative regulation of potassium ion transport positive regulation of GTPase activity response to ethanol negative regulation of cell cycle positive regulation of protein kinase activity positive regulation of vasodilation positive regulation of transcription from RNA polymerase II promoter ATP metabolic process positive regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential positive regulation of growth hormone secretion negative regulation of glial cell proliferation positive regulation of ERK1 and ERK2 cascade regulation of oligodendrocyte progenitor proliferation cellular response to glucocorticoid stimulus positive regulation of chemokine (C-C motif) ligand 5 production positive regulation of somatostatin secretion
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