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Invitrogen
PACS2 Polyclonal Antibody
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Product Details
PA5-100167
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PACS2(Accession Q86VP3), corresponding to amino acid residues S707-P757.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2815697
Product Specific Information
Antibody detects endogenous levels of total PACS2.
Target Information
PACS2 is the multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, PACS2 translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death.PACS2 may also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ25488; PACS-2; PACS1-like protein; Phosphofurin acidic cluster sorting protein 2
Gene Aliases: 6720425G15Rik; AW208651; AW489976; E230011J22; KIAA0602; mKIAA0602; PACS-2; PACS1L; PACS2
UniProt ID: (Human) Q86VP3, (Mouse) Q3V3Q7
Entrez Gene ID: (Human) 23241, (Mouse) 217893, (Rat) 691631
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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