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Invitrogen
PACS2 Polyclonal Antibody
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Product Details
PA5-51575
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PACS2. Recombinant protein control fragment (Product #RP-89005).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2645161
Product Specific Information
Immunogen sequence: LAWRDLFNKL EAQSAVQDTP DIVSRITQYI AGANCAHQLP IAEAMLTYKQ KSPDEESSQK FIPFVGVVKV GIVEPSSATS GDSDDAAPSG SGTLSSTPPS ASPAAKEASP TPPSSPSVSG G
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 94%.
Target Information
PACS2 is the multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, PACS2 translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death.PACS2 may also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ25488; PACS-2; PACS1-like protein; Phosphofurin acidic cluster sorting protein 2
Gene Aliases: KIAA0602; PACS-2; PACS1L; PACS2
UniProt ID: (Human) Q86VP3
Entrez Gene ID: (Human) 23241
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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