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Invitrogen
PADI2 Polyclonal Antibody
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FIGURE: 1 / 9
PADI2 Antibody (PA5-61579) in ICC/IF
Immunofluorescence analysis of PADI2 was performed using 70% confluent log phase A-549 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with PADI2 Polyclonal Antibody (Product # PA5-61579) at 1:100 dilution in 0.1% BSA and incubated overnight at 4 degree and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Recombinant Secondary Antibody, Alexa Fluor® 488 conjugate (Product... View More
Product Details
PA5-61579
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PADI2. Recombinant protein control fragment (Product #RP-103009).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2645162
Product Specific Information
Immunogen sequence: PWLPKEDCRD EKVYSKEDLK DMSQMILRTK GPDRLPAGYE IVLYISMSDS DKVGVFYVEN PFFGQRYIHI LGRRKLYHVV KYTGGS
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.
Target Information
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: PAD-H19; peptidyl arginine deiminase, type II; Peptidylarginine deiminase II; Protein-arginine deiminase type II; Protein-arginine deiminase type-2; RP1-37C10.6
Gene Aliases: KIAA0994; PAD-H19; PAD2; PADI2; PDI2
UniProt ID: (Human) Q9Y2J8
Entrez Gene ID: (Human) 11240
chromatin organization
regulation of chromatin disassembly
protein citrullination
substantia nigra development
intracellular estrogen receptor signaling pathway
histone H3-R26 citrullination
chromatin-mediated maintenance of transcription
negative regulation of chemokine-mediated signaling pathway
negative regulation of lymphocyte chemotaxis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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