Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
PADI4 Polyclonal Antibody
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
PA5-110070
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 290-663 of human PADI4 (NP_0365192)
Conjugate
Form
Liquid
Concentration
2.08 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2855481
Product Specific Information
Immunogen sequence: VFRVAPWIMT PNTQPPQEVY ACSIFENEDF LKSVTTLAMK AKCKLTICPE EENMDDQWMQ DEMEIGYIQA PHKTLPVVFD SPRNRGLKEF PIKRVMGPDF GYVTRGPQTG GISGLDSFGN LEVSPPVTVR GKEYPLGRIL FGDSCYPSND SRQMHQALQD FLSAQQVQAP VKLYSDWLSV GHVDEFLSFV PAPDRKGFRL LLASPRSCYK LFQEQQNEGH GEALLFEGIK KKKQQKIKNI LSNKTLREHN SFVERCIDWN RELLKRELGL AESDIIDIPQ LFKLKEFSKA EAFFPNMVNM LVLGKHLGIP KPFGPVINGR CCLEEKVCSL LEPLGLQCTF INDFFTYHIR HGEVHCGTNV RRKPFSFKWW NMVP
Target Information
Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at 'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: HL-60 PAD; PAD type IV; PAD-R4; PADI-H protein; peptidyl arginine deiminase, type 4; peptidyl arginine deiminase, type IV; peptidyl arginine deiminase, type V; Peptidylarginine deiminase IV; Peptidylarginine deiminase type alpha; Protein-arginine deiminase type IV; Protein-arginine deiminase type-4
Gene Aliases: PAD; PAD4; PADI4; PADI5; PDI4; PDI5
UniProt ID: (Human) Q9UM07, (Rat) O88807, (Mouse) Q9Z183
Entrez Gene ID: (Human) 23569, (Rat) 29512, (Mouse) 18602
chromatin organization
nucleosome assembly
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
cellular protein modification process
chromatin modification
protein citrullination
stem cell population maintenance
histone H3-R26 citrullination
histone citrullination
innate immune response
immune system process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support