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Invitrogen
PADI4 Polyclonal Antibody
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Product Details
PA5-29880
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the N-terminus region of human PAD4. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2547354
Product Specific Information
Recommended positive controls: PAD4-transfected 293T.
Predicted reactivity: Human (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at 'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HL-60 PAD; PADI-H protein; peptidyl arginine deiminase, type IV; peptidyl arginine deiminase, type V; Peptidylarginine deiminase IV; Protein-arginine deiminase type IV; Protein-arginine deiminase type-4
Gene Aliases: PAD; PAD4; PADI4; PADI5; PDI4; PDI5
UniProt ID: (Human) Q9UM07
Entrez Gene ID: (Human) 23569
chromatin organization
nucleosome assembly
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
cellular protein modification process
chromatin modification
protein citrullination
stem cell population maintenance
histone H3-R26 citrullination
histone citrullination
innate immune response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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