Invitrogen

PAI1 Polyclonal Antibody

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-88349

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 24-158 of human PAI-1/Serpin E1 (NP_0005931)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804848

Product Specific Information

Immunogen sequence: VHHPPSYVAH LASDFGVRVF QQVAQASKDR NVVFSPYGVA SVLAMLQLTT GGETQQQIQA AMGFKIDDKG MAPALRHLYK ELMGPWNKDE ISTTDAIFVQ RDLKLVQGFM PHFFRLFRST VKQVDFSEVE RARFI; Positive Samples: HT-1080, SH-SY5Y, Mouse brain, Rat liver

Target Information

PAI1 (plasminogen activator inhibitor 1) belongs to serine protease inhibitor superfamily, and is the principal inhibitor of tissue-type and urokinase-type plasminogen activators (tPA and uPA). Platelets are the main source of the circulating PAI11, but it is synthesized and secreted by many tissue and cell types, including fibroblasts, smooth muscle cells, endothelial cells, hepatocytes, and inflammatory cells. Expression of PAI11 can be regulated at the transcriptional level by many factors including growth factors, cytokines, hormones, inflammatory factors, glucose or lipid metabolites, vascular tone regulating factors, chemicals, and other environmental or physical factors. PAI1 is present at increased levels in various disease states, and has been linked to an increased occurrence of thrombosis in obesity, thrombophilia and the metabolic syndrome. Defects in PAI-1 are characterized by abnormal bleeding. PAI1 mediates inhibition of fibrinolysis by inhibiting the activity of plasminogen activator, and may promote neuronal survival. Other defects in PAI1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency). Alternatively spliced transcript variants encoding different isoforms of PAI1 have been found.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Endothelial plasminogen activator inhibitor; nexin, plasminogen activator inhibitor type 1; PAI; PAI-1; plas; Plasminogen activator inhibitor 1; plasminogen activator inhibitor, type I; Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI); serine (or cysteine) peptidase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serine (or cysteine) proteinase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, member 1; Serpin E1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; SERPINE-1

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Gene Aliases: PAI; PAI-1; PAI1; PAI1A; Pai1aa; Planh; PLANH1; RATPAI1A; SERPINE1

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UniProt ID: (Human) P05121, (Rat) P20961

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Entrez Gene ID: (Human) 5054, (Mouse) 18787, (Rat) 24617

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Function(s)
protease binding serine-type endopeptidase inhibitor activity receptor binding protein binding peptidase inhibitor activity
Process(es)
chronological cell aging angiogenesis platelet degranulation circadian rhythm regulation of receptor activity negative regulation of plasminogen activation negative regulation of endopeptidase activity negative regulation of smooth muscle cell migration positive regulation of blood coagulation negative regulation of blood coagulation extracellular matrix organization negative regulation of cell migration positive regulation of interleukin-8 production negative regulation of cell adhesion mediated by integrin positive regulation of leukotriene production involved in inflammatory response fibrinolysis positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter positive regulation of receptor-mediated endocytosis positive regulation of inflammatory response defense response to Gram-negative bacterium negative regulation of fibrinolysis negative regulation of vascular wound healing negative regulation of wound healing cellular response to lipopolysaccharide positive regulation of monocyte chemotaxis negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of smooth muscle cell-matrix adhesion negative regulation of endothelial cell apoptotic process female gonad development negative regulation of peptidase activity positive regulation of gene expression negative regulation of gene expression cellular response to drug wound healing regulation of cell proliferation regulation of angiogenesis positive regulation of fibroblast proliferation positive regulation of coagulation positive regulation of keratinocyte migration cellular response to interleukin-1 cellular response to transforming growth factor beta stimulus positive regulation of calcium ion import response to reactive oxygen species response to lipopolysaccharide cellular response to insulin stimulus response to cytokine response to laminar fluid shear stress cellular response to potassium ion cellular response to platelet-derived growth factor stimulus tissue regeneration glucose homeostasis response to starvation response to estrogen cellular response to fibroblast growth factor stimulus mast cell activation negative regulation of proteolysis decidualization response to hyperoxia cellular response to hydrogen peroxide response to epidermal growth factor cellular response to metal ion cellular response to gravity cellular response to mechanical stimulus cellular response to nicotine cellular response to ATP cellular response to cAMP cellular response to cGMP cellular response to glucose stimulus cellular response to growth factor stimulus cellular response to follicle-stimulating hormone stimulus cellular response to glucagon stimulus cellular response to low-density lipoprotein particle stimulus cellular response to organic cyclic compound cellular response to cycloheximide cellular response to hypoxia cellular response to dexamethasone stimulus response to transforming growth factor beta cellular response to nerve growth factor stimulus
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