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Abnova
PAK2 Polyclonal Antibody, MaxPab™
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FIGURE: 1 / 1
PAK2 Antibody (H00005062-D01P) in WB
Western Blot analysis of PAK2 expression in transfected 293T cell line (H00005062-T02) by PAK2 MaxPab polyclonal antibody.
Lane 1: PAK2 transfected lysate(58.00 KDa).
Lane 2: Non-transfected lysate.
Lane 1: PAK2 transfected lysate(58.00 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00005062-D01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PAK2 (NP_002568.2, 1 a.a. approximately 524 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MSDNGELEDK PPAPPVRMSS TIFSTGGKDP LSANHSLKPL PSVPEEKKPR HKIISIFSGT EKGSKKKEKE RPEISPPSDF EHTIHVGFDA VTGEFTGMPE QWARLLQTSN ITKLEQKKNP QAVLDVLKFY DSNTVKQKYL SFTPPEKDGF PSGTPALNAK GTEAPAVVTE EEDDDEETAP PVIAPRPDHT KSIYTRSVID PVPAPVGDSH VDGAAKSLDK QKKKTKMTDE EIMEKLRTIV SIGDPKKKYT RYEKIGQGAS GTVFTATDVA LGQEVAIKQI NLQKQPKKEL IINEILVMKE LKNPNIVNFL DSYLVGDELF VVMEYLAGGS LTDVVTETCM DEAQIAAVCR ECLQALEFLH ANQVIHRDIK SDNVLLGMEG SVKLTDFGFC AQITPEQSKR STMVGTPYWM APEVVTRKAY GPKVDIWSLG IMAIEMVEGE PPYLNENPLR ALYLIATNGT PELQNPEKLS PIFRDFLNRC LEMDVEKRGS AKELLQHPFL KLAKPLSSLT PLIMAAKEAM KSNR
Target Information
PAK2 (serine/threonine-protein kinase PAK2) is a serine/threonine kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis, or proliferation. It acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformation change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha-PAK; Beta-PAK; gamma pak; Gamma-PAK; Oligophrenin-3; OPHN3; p21 (CDKN1A)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 2; p21-activated kinase 2; p58; p65-PAK; PAK alpha; PAK beta; PAK gamma; PAK-1; PAK-2; PAK-3; PAK1; PAK3; PAK65; S6/H4 kinase; Serine/threonine-protein kinase PAK 2
Gene Aliases: PAK2; PAK65; PAKgamma
UniProt ID: (Human) Q13177
Entrez Gene ID: (Human) 5062
mitotic cell cycle
stimulatory C-type lectin receptor signaling pathway
protein phosphorylation
negative regulation of protein kinase activity
apoptotic process
signal transduction
viral process
phosphorylation
peptidyl-serine phosphorylation
signal transduction by protein phosphorylation
T cell costimulation
Fc-epsilon receptor signaling pathway
regulation of growth
negative regulation of apoptotic process
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
regulation of defense response to virus by virus
positive regulation of peptidyl-tyrosine phosphorylation
T cell receptor signaling pathway
dendritic spine development
positive regulation of protein tyrosine kinase activity
cellular response to organic cyclic compound
cell-cell adhesion
positive regulation of extrinsic apoptotic signaling pathway
negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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