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Product Details
PA5-120128
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 450-550 of human PAK4 (NP_005875.1).
Conjugate
Form
Liquid
Concentration
2.65 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2913700
Product Specific Information
Positive test controls include: LNCaP, Mouse testis, Mouse brain. The target is usually found in the following locations: Cytoplasm.
Immunogen sequence: HDGRVKLSDF GFCAQVSKEV PRRKSLVGTP YWMAPELISR LPYGPEVDIW SLGIMVIEMV DGEPPYFNEP PLKAMKMIRD NLPPRLKNLH KVSPSLKGFL D
Target Information
PAK4 is a serine/ threonine p21 activating kinase implicated in the reorganization of actin cytoskeleton and in the formation of filopodia. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. The second group includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK4 was initially identified as a novel effector of Cdc42Hs. Co-expression of PAK4 and Cdc42Hs resulted in induction of filopodia and actin polymerization, showing that it is involved in cytoskeletal reorganization. Other experiments have shown PAK4 to be essential for embryonic viability and proper neuronal development. PAK4 has also been implicated in anchorage-independent growth of tumor cells and is required for activation of several cancer prosurvival pathways.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: p21-activated kinase 4; PAK-4; Serine/threonine-protein kinase PAK 4
Gene Aliases: 5730488L07Rik; AW555722; Kiaa1142; mKIAA1142; Pak4
UniProt ID: (Mouse) Q8BTW9
Entrez Gene ID: (Mouse) 70584
protein phosphorylation
Rho protein signal transduction
regulation of mitotic cell cycle
cell migration
signal transduction by protein phosphorylation
actin cytoskeleton organization
stress-activated protein kinase signaling cascade
activation of protein kinase activity
regulation of apoptotic process
regulation of MAPK cascade
dendritic spine development
cellular response to organic cyclic compound
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