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Product Details
12595-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PANX1 Fusion Protein Ag3174 (126-426 aa encoded by BC016931)
Conjugate
Form
Liquid
Concentration
0.14 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: FWRFAAAPH ICSDLKFIME ELDKVYNRAI KAAKSARDLD MRDGACSVPG VTENLGQSLW EVSESHFKYP IVEQYLKTKK NSNNLIIKYI SCRLLTLIII LLACIYLGYY FSLSSLSDEF VCSIKSGILR NDSTVPDQFQ CKLIAVGIFQ LLSVINLVVY VLLAPVVVYT LFVPFRQKTD VLKVYEILPT FDVLHFKSEG YNDLSLYNLF LEENISEVKS YKCLKVLENI KSSGQGIDPM LLLTNLGMIK MDVVDGKTPM SAEMREEQGN QTAELQGMNI DSETKANNGE KNARQRLLDS SC (126-426 aa encoded by BC016931)
Target Information
The pannexin gene family encodes a second class of putative gap junction proteins and are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels. Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 is a transmembrane protein that forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. PANX1 may play a role as a Ca2+ -leak channel to regulate ER Ca2+ homeostasis and regulates neural stem and progenitor cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: innexin; Pannexin-1; PANX1
Gene Aliases: AI847747; MRS1; PANX1; PX1; UNQ2529; UNQ2529/PRO6028
UniProt ID: (Human) Q96RD7, (Mouse) Q9JIP4
Entrez Gene ID: (Human) 24145, (Mouse) 55991
protease binding
receptor binding
calcium channel activity
leak channel activity
ion channel binding
protein heterodimerization activity
actin filament binding
gap junction hemi-channel activity
scaffold protein binding
actin binding
gap junction channel activity
protein binding
channel activity
wide pore channel activity
response to ischemia
cation transport
calcium ion transport
cell-cell signaling
response to ATP
protein hexamerization
positive regulation of interleukin-1 alpha secretion
positive regulation of interleukin-1 beta secretion
calcium ion transmembrane transport
transport
ion transport
positive regulation of cytokine secretion
transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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