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Proteintech
PANX2 Polyclonal Antibody
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Product Details
26604-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PANX2 Fusion Protein Ag24256 (70-170 aa encoded by BC101023)
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Product # 26604-1-AP specifically recognizes the 70 kDa Panx2.
Immunogen sequence: ESDLMYDNV VRQLLAALAQ SNHDATPTVR DSGVQTVDPS ANPAEPDGAA EPPVVKRPRK KMKWIPTSNP LPQPFKEPLA IMRVENSKAE KPKPARRKTA TD (70-170 aa encoded by BC101023)
Target Information
Gap junctions are channel-forming structures that allow direct metabolic and electrical communication between adjacent cells of almost all types in mammalian tissues. In the human body, they are absent only in adult skeletal muscle cells and some circulating blood cells. A gap junction is formed two hemichannels, one in each of the neighboring cells, composed of six subunits. In mice and humans, at least 20 connexin and 3 pannexin genes encode gap junction proteins. Connexins are only found in chordates, while pannexins are present in both chordate and invertebrate genomes. Pannexins, previously known as innexins, are predicted to have four transmembrane regions, two extracellular loops, one intracellular loop, and intracellular N- and C-termini. Both human and mouse genomes contain three pannexin-encoded genes. Pannexin 2 (Px2, PANX2) appears to be a brain specific gene, and is abundantly expressed in the central nervous system, as is pannexin 1. In many neuronal cell populations, including hippocampus, olfactory bulb, cortex, and cerebellum, pannexin 1 and pannexin 2 are co-expressed; in other brain regions such as white matter, only pannexin 1-positive cells are found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: h PX2; Pannexin-2
Gene Aliases: hPANX2; PANX2; PX2
UniProt ID: (Human) Q96RD6, (Mouse) Q6IMP4
Entrez Gene ID: (Human) 56666, (Mouse) 406218
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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