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Bioss
PAPOL A+B+G Polyclonal Antibody
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FIGURE: 1 / 1
PAPOL A+B+G Antibody (BS-9435R) in WB
Lane 1: rat kidney lysates Lane 2: rat brain lysates probed with Anti PAP-alpha/beta/gamma Polyclonal Antibody, Unconjugated (bs-9435R) at 1:200 in 4°C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:3,000 90 min in 37°C. Predicted band 70-82 kD. Observed band size: 75 kDa.
Product Details
BS-9435R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PAPOLA/PAPOLB/PAPOLG.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Polyadenylation of the 3-prime ends of eukaryotic mRNAs is a key event that takes place in the nucleus during maturation of mRNA. The reaction includes endoribonucleolytic cleavage of the pre-RNA at the poly(A) site that leads to synthesis of the poly(A) tail at the 3-prime end of the upstream cleavage product. The poly(A) polymerase (PAP) is required The adenosine addition reaction depends on poly(A) polymerase (PAP) activity. The testis express PAP-beta (TPAP) in the cytoplasm of spermatogenic cells. The adenosine addition function of PAP-beta plays a critical role in male germ cell production. PAP-beta-deficient transgenic mice display impaired expression of haploid-specific genes that are necessary for spermatogenesis. The intronless gene encoding human PAP-beta maps to chromosome 7p22.3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Neo-PAP; Neo-poly(A) polymerase; nuclear poly(A) polymerase gamma; PAP-alpha; PAP-beta; PAP-gamma; Poly(A) polymerase alpha; Poly(A) polymerase beta; poly(A) polymerase beta (testis specific); Poly(A) polymerase gamma; Polynucleotide adenylyltransferase; Polynucleotide adenylyltransferase alpha; Polynucleotide adenylyltransferase beta; Polynucleotide adenylyltransferase gamma; Signal recognition particle RNA-adenylating enzyme; SRP 3'-adenylating protein; SRP RNA 3' adenylating enzyme/pap2; SRP RNA 3'-adenylating enzyme; SRP RNA-adenylating enzyme; Testis-specific poly(A) polymerase
Gene Aliases: 9630006B20Rik; PAP; PAP2; PAPG; PapIII; Paplob; PAPOLA; Papola-ps; PAPOLB; PAPOLG; PAPT; Plap; Plap-ps; TPAP
UniProt ID: (Human) P51003, (Human) Q9NRJ5, (Human) Q9BWT3, (Mouse) Q61183, (Mouse) Q9WVP6, (Mouse) Q6PCL9
Entrez Gene ID: (Human) 10914, (Human) 56903, (Human) 64895, (Mouse) 18789, (Rat) 314417, (Rat) 304300, (Mouse) 56522, (Mouse) 216578, (Rat) 305586
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