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Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 ). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2.
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Protein Aliases: 3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1; adenylyl-sulfate kinase; Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1; PAPS synthase 1; PAPS Synthetase 1; PAPSS 1; SK 1; sulfate adenylyltransferase; Sulfurylase kinase 1
Gene Aliases: AI325286; Asapk; ATPSK1; PAPSS; PAPSS1; SK1
UniProt ID: (Human) O43252, (Mouse) Q60967
Entrez Gene ID: (Human) 9061, (Mouse) 23971, (Rat) 295443
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