Invitrogen

PAR1 Polyclonal Antibody

View all (18) PAR1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-116040

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
- -

Immunohistochemistry (IHC)

-
- -

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human F2R(Accession P25116), corresponding to amino acid residues M1-N47.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2900674

Product Specific Information

Antibody detects endogenous levels of total Thrombin Receptor.

Target Information

Thrombin is a serine protease that is involved in platelet aggregation and blood coagulation. It is cleaved from its precursor, prothrombin, and converts fibrinogen to fibrin in the final step of the clotting cascade. Thrombin mediates its regulatory effects by activating cell surface G-protein coupled receptors which include PAR-1, PAR-2 and PAR3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C HTR; coagulation factor II (thrombin) receptor; Coagulation factor II receptor; PAR-1; protease activated receptor 1; protease-activated receptor 1; Proteinase-activated receptor 1; Thrombin receptor

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Gene Aliases: AI482343; CF2R; F2R; HTR; PAR-1; PAR1; ThrR; TR; TRGPC

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UniProt ID: (Human) P25116, (Mouse) P30558

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Entrez Gene ID: (Human) 2149, (Mouse) 14062, (Rat) 25439

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Function(s)
G-protein alpha-subunit binding G-protein coupled receptor activity receptor binding protein binding thrombin receptor activity G-protein beta-subunit binding signal transducer activity heterotrimeric G-protein binding
Process(es)
activation of MAPKK activity connective tissue replacement involved in inflammatory response wound healing negative regulation of glomerular filtration activation of cysteine-type endopeptidase activity involved in apoptotic process inflammatory response signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration protein kinase C-activating G-protein coupled receptor signaling pathway tyrosine phosphorylation of STAT protein STAT protein import into nucleus establishment of synaptic specificity at neuromuscular junction blood coagulation hemostasis positive regulation of cell proliferation negative regulation of cell proliferation response to wounding positive regulation of phosphatidylinositol 3-kinase signaling obsolete death platelet activation regulation of blood coagulation positive regulation of blood coagulation positive regulation of cell migration response to lipopolysaccharide regulation of interleukin-1 beta production positive regulation of collagen biosynthetic process positive regulation of Rho protein signal transduction positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of transcription, DNA-templated positive regulation of vasoconstriction positive regulation of smooth muscle contraction positive regulation of JAK-STAT cascade homeostasis of number of cells within a tissue release of sequestered calcium ion into cytosol positive regulation of release of sequestered calcium ion into cytosol positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway positive regulation of calcium ion transport regulation of sensory perception of pain positive regulation of ERK1 and ERK2 cascade thrombin receptor signaling pathway negative regulation of renin secretion into blood stream positive regulation of interleukin-8 secretion positive regulation of interleukin-6 secretion anatomical structure morphogenesis positive regulation of I-kappaB kinase/NF-kappaB signaling platelet dense granule organization
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