Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
PAR4 Recombinant Rabbit Monoclonal Antibody (10Q2G9)
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
MA5-38130
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
10Q2G9
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 241-340 of human PAR4 (Q96IZ0)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2898048
Product Specific Information
Positive Samples: HeLa, SW620, 293T, Mouse lung
Immunogen sequence: YSRTDRSGFP RYNRDANVSG TLVSSSTLEK KIEDLEKEVV RERQENLRLV RLMQDKEEMI GKLKEEIDLL NRDLDDIEDE NEQLKQENKT LLKVVGQLTR
Target Information
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Par-4; PRKC apoptosis WT1 regulator protein; PRKC, apoptosis, WT1, regulator; prostate apoptosis response 4; Prostate apoptosis response 4 protein; prostate apoptosis response protein 4; prostate apoptosis response protein PAR-4; prostate apoptosis response-4; transcriptional repressor PAR4; WT1-interacting protein
Gene Aliases: 2310001G03Rik; Par-4; PAR4; PAWR
UniProt ID: (Human) Q96IZ0, (Mouse) Q925B0
Entrez Gene ID: (Human) 5074, (Mouse) 114774
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
apoptotic process
response to wounding
response to iron(II) ion
negative regulation of B cell proliferation
response to lipopolysaccharide
positive regulation of phosphoprotein phosphatase activity
interleukin-2 biosynthetic process
negative regulation of T cell proliferation
positive regulation of amyloid precursor protein biosynthetic process
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
negative regulation of T cell receptor signaling pathway
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
actin filament bundle assembly
positive regulation of hindgut contraction
cellular response to vitamin E
cellular response to interleukin-1
cellular response to follicle-stimulating hormone stimulus
cellular response to estradiol stimulus
negative regulation of calcium ion import
apoptotic signaling pathway
activation of cysteine-type endopeptidase activity
positive regulation of relaxation of smooth muscle
positive regulation of leukocyte tethering or rolling
positive regulation of neuronal action potential
calcium ion import into cell
positive regulation of neutrophil extravasation
regulation of transcription, DNA-templated
positive regulation of action potential
regulation of neuronal action potential
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support