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Proteintech
PARL Polyclonal Antibody
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Product Details
26679-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PARL Fusion Protein Ag24789 (56-167 aa encoded by BC014058)
Conjugate
Form
Liquid
Concentration
0.47 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: APRKVEPRR SDPGTSGEAY KRSALIPPVE ETVFYPSPYP IRSLIKPLFF TVGFTGCAFG SAAIWQYESL KSRVQSYFDG IKADWLDSIR PQKEGDFRKE INKWWNNLSD GQR (56-167 aa encoded by BC014058)
Target Information
This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Mitochondrial intramembrane cleaving protease PARL; mitochondrial intramembrane-cleaving protease PARL; Presenilin-associated rhomboid-like protein, mitochondrial; rhomboid 7 homolog 1
Gene Aliases: PARL; PRO2207; PSARL; PSARL1; PSENIP2; RHBDS1
UniProt ID: (Human) Q9H300
Entrez Gene ID: (Human) 55486
proteolysis
protein processing
regulation of proteolysis
membrane protein proteolysis
negative regulation of release of cytochrome c from mitochondria
regulation of mitophagy
regulation of protein targeting to mitochondrion
regulation of reactive oxygen species metabolic process
negative regulation of intrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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