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Product Details
600-401-J27
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PARL affinity purified antibody was prepared from whole rabbit serum produced by repeated immunization from a synthetic peptide corresponding to the C terminus region of human PARL.
Conjugate
Form
Liquid
Concentration
0.86 mg/mL
Purification
Affinity chromatography
Storage buffer
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl, 50% glycerol
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Anti-PARL specific towards PARL. A BLAST analysis was used to suggest cross-reactivity with Human, Mouse, Rat, Chicken, and Primate based on 100% sequence homology. Cross-reactivity with PARL (presenilin associated, rhomboid-like) from other sources has not been determined.
Target Information
This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Mitochondrial intramembrane cleaving protease PARL; Mitochondrial intramembrane-cleaving protease PARL; parl {ECO:0000250|UniProtKB:Q9H300}; Presenilin-associated rhomboid-like protein, mitochondrial; presenilins-associated rhomboid-like protein, mitochondrial; rhomboid 7 homolog 1
Gene Aliases: D16Ertd607e; PARL; PRO2207; PSARL; PSARL1; PSENIP2; RHBDS1
UniProt ID: (Human) Q9H300, (Mouse) Q5XJY4, (Rat) Q3B8P0
Entrez Gene ID: (Human) 55486, (Mouse) 381038, (Rat) 287979
proteolysis
protein processing
regulation of proteolysis
negative regulation of release of cytochrome c from mitochondria
regulation of mitophagy
regulation of protein targeting to mitochondrion
regulation of reactive oxygen species metabolic process
negative regulation of intrinsic apoptotic signaling pathway
membrane protein proteolysis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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