Proteintech

PARP1 Polyclonal Antibody, CoraLite® Plus 647

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

CL647-13371

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cell suspension
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein
View immunogen

Conjugate

CoraLite® Plus 647 CoraLite® Plus 647 CoraLite® Plus 647

Excitation/Emission Max

654/674 nm

Form

Liquid

Purification

Antigen affinity chromatography

Storage buffer

PBS with 0.5% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: PKPVQDLIKM IFDVESMKKA MVEYEIDLQK MPLGKLSKRQ IQAAYSILSE VQQAVSQGSS DSQILDLSNR FYTLIPHDFG MKKPPLLNNA DSVQAKAEML DNLLDIEVAY SLLRGGSDDS SKDPIDVNYE KLKTDIKVVD RDSEEAEIIR KYVKNTHATT HNAYDLEVID IFKIEREGEC QRYKPFKQLH NRRLLWHGSR TTNFAGILSQ GLRIAPPEAP VTGYMFGKGI YFADMVSKSA NYCHTSQGDP IGLILLGEVA LGNMYELKHA SHISKLPKGK HSVKGLGKTT PDPSANISLD GVDVPLGTGI SSGVNDTSLL YNEYIVYDIA QVNLKYLLKL KFNFKTSLW

Target Information

Poly ADP-Ribose Polymerase (PARP) uses nicotinamide adenine dinucleotide (oxidized form) NAD as a substrate to catalyse the transfer of ADP-ribose to a variety of nuclear protein acceptors. Proteolysis of PARP to its stable 85kDa fragment is an early marker of programmed cell death (apoptosis) and is mediated by the caspase CPP32 protein. Cleavage occurs between Adp216 and Gly217, a site in PARP conserved across species.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ADP-ribosyltransferase (NAD+; ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 1; ADP-ribosyltransferase 1; ADP-ribosyltransferase diphtheria toxin-like 1; ADP-ribosyltransferase NAD(+); ADPRT 1; ARTD1; DNA ADP-ribosyltransferase PARP1; msPARP; NAD(+) ADP-ribosyltransferase 1; NAD(+) pADPRT-1; PARP-1; poly (ADP-ribose) polymerase 1; poly (ADP-ribose) polymerase family, member 1; poly (ADP-ribose) polymerase); Poly [ADP-ribose] polymerase 1; poly(ADP-ribose) polymerase; poly(ADP-ribose) polymerase PARP-1; poly(ADP-ribose) synthetase; poly(ADP-ribosyl)transferase; Poly[ADP-ribose] synthase 1; poly[ADP-ribose] synthetase 1; Protein poly-ADP-ribosyltransferase PARP1

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Gene Aliases: 5830444G22Rik; Adprp; ADPRT; ADPRT 1; ADPRT1; AI893648; ARTD1; C80510; pADPRT-1; PARP; PARP-1; PARP1; PPOL; sPARP-1

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UniProt ID: (Human) P09874, (Rat) P27008

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Entrez Gene ID: (Human) 142, (Rat) 25591, (Mouse) 11545

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Function(s)
DNA binding DNA ligase (ATP) activity NAD+ ADP-ribosyltransferase activity protein binding transcription factor binding zinc ion binding enzyme binding protein kinase binding identical protein binding histone deacetylase binding poly(A) RNA binding protein N-terminus binding NAD binding R-SMAD binding transferase activity, transferring pentosyl groups chromatin binding transferase activity transferase activity, transferring glycosyl groups metal ion binding
Process(es)
telomere maintenance DNA metabolic process base-excision repair double-strand break repair transcription, DNA-templated protein ADP-ribosylation transforming growth factor beta receptor signaling pathway protein autoprocessing signal transduction involved in regulation of gene expression cellular response to insulin stimulus regulation of growth rate DNA damage response, detection of DNA damage positive regulation of transcription from RNA polymerase II promoter positive regulation of SMAD protein import into nucleus protein poly-ADP-ribosylation cellular response to superoxide positive regulation of transcription regulatory region DNA binding negative regulation of transcription from RNA polymerase II promoter nucleotide-excision repair, DNA damage recognition nucleotide-excision repair, DNA duplex unwinding double-strand break repair via homologous recombination lagging strand elongation DNA repair nucleotide-excision repair, preincision complex stabilization nucleotide-excision repair, preincision complex assembly nucleotide-excision repair, DNA incision, 3'-to lesion nucleotide-excision repair, DNA incision, 5'-to lesion transcription from RNA polymerase II promoter cellular response to DNA damage stimulus mitochondrion organization positive regulation of cardiac muscle hypertrophy protein sumoylation macrophage differentiation mitochondrial DNA metabolic process nucleotide-excision repair, DNA incision cellular response to oxidative stress protein modification process mitochondrial DNA repair DNA ligation involved in DNA repair global genome nucleotide-excision repair regulation of cellular protein localization negative regulation of telomere maintenance via telomere lengthening ATP generation from poly-ADP-D-ribose regulation of transcription, DNA-templated behavioral response to cocaine regulation of single strand break repair
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