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Product Details
26225-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PATZ1 Fusion Protein Ag23912 (1-350 aa encoded by BC021091)
Conjugate
Form
Liquid
Concentration
0.53 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MERVNDASC GPSGCYTYQV SRHSTEMLHN LNQQRKNGGR FCDVLLRVGD ESFPAHRAVL AACSEYFESV FSAQLGDGGA ADGGPADVGG ATAAPGGGAG GSRELEMHTI SSKVFGDILD FAYTSRIVVR LESFPELMTA AKFLLMRSVI EICQEVIKQS NVQILVPPAR ADIMLFRPPG TSDLGFPLDM TNGAALAANS NGIAGSMQPE EEAARAAGAA IAGQASLPVL PGVDRLPMVA GPLSPQLLTS PFPSVASSAP PLTGKRGRGR PRKANLLDSM FGSPGGLREA GILPCGLCGK VFTDANRLRQ HEAQHGVTSL QLGYIDLPPP RLGENGLPIS EDPDGPRKRS R (1-350 aa encoded by BC021091)
Target Information
The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36. 1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BTB-POZ domain zinc finger transcription factor; BTB/POZ domain zinc finger transcription factor; MAZ-related factor; POZ (BTB) and AT hook containing zinc finger 1; POZ-, AT hook-, and zinc finger-containing protein 1; POZ-AT hook-zinc finger protein; Protein kinase A RI subunit alpha-associated protein; transcription factor (MAZ-related) MAZR; zi; Zinc finger and BTB domain-containing protein 19; Zinc finger protein 278; Zinc finger sarcoma gene protein
Gene Aliases: 8430401L15Rik; AI447519; dJ400N23; MAZR; PATZ; PATZ1; RIAZ; ZBTB19; Zfp278; ZNF278; ZSG
UniProt ID: (Human) Q9HBE1
Entrez Gene ID: (Human) 23598, (Mouse) 56218
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
spermatogenesis
male gonad development
T cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of gene expression
positive regulation of transcription, DNA-templated
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