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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • PAX2 Antibodies

          Invitrogen

          PAX2 Polyclonal Antibody

          127 References
          View all (38) PAX2 antibodies

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          Datasheet
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          Datasheet
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          Cite PAX2 Polyclonal Antibody

          • Antibody Testing Data (1)
          PAX2 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.
          PAX2 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          PAX2 Antibody (71-6000) in WB

          Western blot of mouse embryonic kidney using Rabbit anti-Pax-2 Polyclonal Antibody (Product # 71-6000). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          PAX2 Antibody in Western Blot (WB)

          Product Details

          71-6000

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          Assay-dependent
          View 7 publications 7 publications

          Immunohistochemistry (IHC)

          Assay-dependent
          View 63 publications 63 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          -
          View 17 publications 17 publications

          Immunohistochemistry (Frozen) (IHC (F))

          -
          View 6 publications 6 publications

          Immunohistochemistry - Free Floating (IHC (Free))

          -
          View 1 publication 1 publication

          Immunocytochemistry (ICC/IF)

          -
          View 22 publications 22 publications

          Flow Cytometry (Flow)

          -
          View 1 publication 1 publication

          ELISA (ELISA)

          Assay-dependent
          -

          Immunoprecipitation (IP)

          Assay-dependent
          -

          Miscellaneous PubMed (MISC)

          -
          View 10 publications 10 publications
          Product Specifications

          Species Reactivity

          Human, Mouse, Sheep, Rat, Xenopus, Zebrafish

          Published species

          Chicken, Cynomolgus monkey, Dog, Human, Mouse, Rat, Rhesus monkey

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          A GST-Pax-2 fusion protein derived from the C-terminal domain (aa188-385) of the murine Pax-2 protein
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.25 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.4

          Contains

          0.1% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2533990

          Target Information

          The pax genes are a family of transcription factors that are active in specific tissues during early embryonic development. Pax family members possess a DNA-binding domain encoded by the paired box. Because paired domain containing genes encode transcription factors, they are capable of executing a genetic program. Several pax genes have also been associated with developmental mutations including: pax-3, which is associated with Waardenburg syndrome, pax-6, which is associated with Aniridia, and pax-2, which is associated with Wilms tumor. During embryogenesis, Pax-2 is expressed in the developing kidney. In particular, the pax-2 gene is expressed in condensing metanephric mesenchyme and in early epithelial structures derived from mesenchyme; however, pax-2 mRNA and protein levels are rapidly down regulated as the tubular epithelium matures. Although Pax-2 is down regulated during renal epithelium maturation, Pax-2 expression persists in the undifferentiated epithelium of Wilms' tumors. Persistent expression of Pax-2 in Wilms' tumors occurs frequently and correlates with the proliferation of poorly differentiated epithelial cells in these tumors. Interestingly, expression of the Wilms' tumor suppresser protein, WT1, coincides with down-regulation of the pax-2 gene; thus, suggesting that WT1 can directly repress pax-2 transcription.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: optic disc coloboma; paired box gene 2; paired box homeotic gene 2; Paired box protein Pax-2

          View more View less

          Gene Aliases: FSGS7; Opdc; PAPRS; Pax-2; PAX2

          View more View less

          UniProt ID: (Human) Q02962, (Mouse) P32114

          View more View less

          Entrez Gene ID: (Sheep) 100422802, (Human) 5076, (Mouse) 18504, (Rat) 293992

          View more View less

          Function(s)
          core promoter proximal region sequence-specific DNA binding DNA binding protein binding transcription factor binding superoxide-generating NADPH oxidase activity transcription regulatory region DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor activity, sequence-specific DNA binding C2H2 zinc finger domain binding sequence-specific DNA binding
          Process(es)
          urogenital system development branching involved in ureteric bud morphogenesis cell fate determination mesonephros development neural tube closure optic cup morphogenesis involved in camera-type eye development mesenchymal to epithelial transition involved in metanephros morphogenesis retinal pigment epithelium development transcription, DNA-templated transcription from RNA polymerase II promoter axonogenesis mesodermal cell fate specification aging visual perception glial cell differentiation optic nerve development optic nerve morphogenesis optic nerve structural organization vestibulocochlear nerve formation response to nutrient levels regulation of metanephros size ureter maturation pronephric field specification inner ear morphogenesis camera-type eye development negative regulation of apoptotic process negative regulation of programmed cell death negative regulation of cysteine-type endopeptidase activity involved in apoptotic process protein kinase B signaling negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of cytolysis positive regulation of transcription from RNA polymerase II promoter pronephros development brain morphogenesis stem cell differentiation positive regulation of epithelial cell proliferation oxidation-reduction process mesenchymal to epithelial transition optic chiasma development cellular response to hydrogen peroxide cellular response to retinoic acid cellular response to glucose stimulus cellular response to epidermal growth factor stimulus metanephric mesenchyme development positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis metanephric mesenchymal cell differentiation nephric duct formation ureter development metanephric collecting duct development metanephric epithelium development metanephric distal convoluted tubule development metanephric nephron tubule formation positive regulation of metanephric glomerulus development negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis regulation of metanephric nephron tubule epithelial cell differentiation reactive oxygen species metabolic process cochlea development cochlea morphogenesis positive regulation of branching involved in ureteric bud morphogenesis negative regulation of mesenchymal cell apoptotic process involved in metanephros development negative regulation of apoptotic process involved in metanephric collecting duct development negative regulation of apoptotic process involved in metanephric nephron tubule development negative regulation of reactive oxygen species metabolic process positive regulation of metanephric DCT cell differentiation positive regulation of optic nerve formation negative regulation of transcription from RNA polymerase II promoter metanephros development ureteric bud development kidney development regulation of transcription, DNA-templated multicellular organism development positive regulation of cell proliferation cell differentiation regulation of apoptotic process regulation of programmed cell death animal organ development paramesonephric duct development renal system development mesonephric tubule development mesonephric tubule formation mesonephric duct development pancreas development cellular response to mechanical stimulus ureter morphogenesis
          It has to be done as per old AB suggested Products section.
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