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Proteintech
PC Monoclonal Antibody (4F5D1)
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Product Details
66615-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
4F5D1
Immunogen
PC Fusion Protein Ag8846 (828-1178 aa encoded by BC011617)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MERVFDYSE YWEGARGLYA AFDCTATMKS GNSDVYENEI PGGQYTNLHF QAHSMGLGSK FKEVKKAYVE ANQMLGDLIK VTPSSKIVGD LAQFMVQNGL SRAEAEAQAE ELSFPRSVVE FLQGYIGVPH GGFPEPFRSK VLKDLPRVEG RPGASLPPLD LQALEKELVD RHGEEVTPED VLSAAMYPDV FAHFKDFTAT FGPLDSLNTR LFLQGPKIAE EFEVELERGK TLHIKALAVS DLNRAGQRQV FFELNGQLRS ILVKDTQAMK EMHFHPKALK DVKGQIGAPM PGKVIDIKVV AGAKVAKGQP LCVLSAMKME TVVTSPMEGT VRKVHVTKDM TLEGDDLILE IE (828-1178 aa encoded by BC011617)
Target Information
Pyruvate Carboxylase requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EC 6.4.1.1; PCB; PYC; Pyruvate carboxylase, mitochondrial; pyruvate decarboxylase; Pyruvic carboxylase
Gene Aliases: PC; PCB; Pcx
UniProt ID: (Human) P11498, (Rat) P52873
Entrez Gene ID: (Human) 5091, (Rat) 25104, (Mouse) 18563
pyruvate metabolic process
gluconeogenesis
oxaloacetate metabolic process
lipid metabolic process
metabolic process
negative regulation of gene expression
viral RNA genome packaging
positive regulation by host of viral release from host cell
positive regulation by host of viral process
positive regulation of phospholipid biosynthetic process
biotin metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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