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Product Details
H00055795-D01P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PCID2 (AAH31246.1, 1 a.a. approximately 397 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MRLTDVVQQL VYEAIDSRDG ASCAELVSFK HPHVANPRLQ MASPEEKCQQ VLEPPYDEMF AAHLRCTYAV GDHDFIEAYK CQTVIVQSFL RAFQAHKEEN WALPVMYAVA LDLRVFANNA DQQLVKKGKS KVGDMLEKAA ELLMSCFRVC ASDTRAGIED SKKWGMLFLV NQLFKIYFKI NKLHLCKPLI RAIDSSNLKD DYSTAQRVTY KYYVGRKAMF DSDFKQAEEY LSFAFEHCHR SSQKNKRMIL IYLLPVKMLL GHMPTVELLK KYHLMQFAEV TRAVSEGNLL LLHEALAKHE AFFIRCGIFL ILEKLKIITY RNLFKKVYLL LKTHQLSLDA FLVALKFMQV EDVDIDEVQC ILANLIYMGH VKGYISHQHQ KLVVSKQNPF PPLSTVC
Target Information
Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CSN12-like protein; PCI domain-containing protein 2; RP11-98F14.6
Gene Aliases: F10; HT004; PCID2
UniProt ID: (Human) Q5JVF3
Entrez Gene ID: (Human) 55795
negative regulation of apoptotic process
regulation of mRNA stability
positive regulation of B cell differentiation
positive regulation of transcription, DNA-templated
spleen development
positive regulation of mitotic cell cycle spindle assembly checkpoint
negative regulation of cysteine-type endopeptidase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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