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Product Details
PA5-67269
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human PCID2. Recombinant protein control fragment (Product #RP-107905).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2663527
Product Specific Information
Immunogen sequence: VCASDTRAGIE DSKKWGMLFL VNQLFKIYFK INKLHLCKPL IRAIDSSNLK DDYSTAQRVT YKYYVGRKAM FDS
Highest antigen sequence identity to the following orthologs - mouse 99%, rat 100%.
Target Information
Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CSN12-like protein; PCI domain-containing protein 2; RP11-98F14.6
Gene Aliases: F10; HT004; PCID2
UniProt ID: (Human) Q5JVF3
Entrez Gene ID: (Human) 55795
negative regulation of apoptotic process
regulation of mRNA stability
positive regulation of B cell differentiation
positive regulation of transcription, DNA-templated
spleen development
positive regulation of mitotic cell cycle spindle assembly checkpoint
negative regulation of cysteine-type endopeptidase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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