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Invitrogen
PCP4 Monoclonal Antibody (CL5306)
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Product Details
MA5-35027
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
CL5306
Immunogen
Recombinant Protein corresonding to Human PCP4
Conjugate
Form
Liquid
Concentration
0.70 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2848932
Product Specific Information
Immunogen sequence: GAGATNGKDK TSGENDGQKK VQEEFDIDMD APETERAAVA IQSQFRKFQK KK
Target Information
PCP-4 (Purkinje cell protein 4), also known as PCP4, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer's disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brain specific polypeptide PEP19; Brain-specific antigen PCP-4; Brain-specific polypeptide PEP-19; Calmodulin regulator protein PCP4; Purkinje cell protein 4
Gene Aliases: P16Rimb19; Pcp-4; PCP4; PEP-19; PEP19; PEPZ19
UniProt ID: (Human) P48539, (Mouse) P63054, (Rat) P63055
Entrez Gene ID: (Human) 5121, (Mouse) 18546, (Rat) 25510
osteoblast differentiation
negative regulation of protein kinase activity
response to osmotic stress
central nervous system development
positive regulation of neuron projection development
positive regulation of dopamine secretion
negative regulation of neuron apoptotic process
cellular response to monosodium glutamate
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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