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Product Details
PA5-100311
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PTPRR(Accession Q15256), corresponding to amino acid residues N532-G582.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2849825
Product Specific Information
Antibody detects endogenous levels of total PTPRR.
Target Information
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domains, and thus represents a receptor-type PTP. The similar gene predominately expressed in mouse brain was found to associate with, and thus regulate the activity and cellular localization of MAP kinases. The rat counterpart of this gene was reported to be regulated by the nerve growth factor, which suggested the function of this gene in neuronal growth and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ch-1 PTPase; Ch-1PTPase; ECPPT; NC-PTPCOM1; PC12-PTP1; Phosphotyrosine phosphatase 13; protein tyrosine phosphatase Cr1PTPase; protein tyrosine phosphatase PCPTP1; protein tyrosine phosphatase, receptor type, R; protein-tyrosine phosphatase NC-PTPCOM1; Protein-tyrosine phosphatase PCPTP1; Protein-tyrosine-phosphatase SL; protein-tyrosine-phosphatase-SL; R-PTP-R; Receptor-type tyrosine-protein phosphatase R; STEP-like PTPase; Tyrosine phosphatase CBPTP
Gene Aliases: EC-PTP; ECPTP; Gmcp1; mPTP213; PCPTP1; Ptp; PTP-SL; Ptp13; PTPBR7; PTPRQ; PTPRR; RPTPRR
UniProt ID: (Human) Q15256, (Mouse) Q62132, (Rat) O08617
Entrez Gene ID: (Human) 5801, (Mouse) 19279, (Rat) 94202
protein dephosphorylation
negative regulation of epithelial cell migration
dephosphorylation
peptidyl-tyrosine dephosphorylation
ERBB2 signaling pathway
negative regulation of ERK1 and ERK2 cascade
in utero embryonic development
nervous system development
neuron differentiation
regulation of homophilic cell adhesion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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