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Invitrogen
PCSK1 Polyclonal Antibody
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PCSK1 Antibody (PA5-29832) in IHC (P)
PCSK1 Polyclonal Antibody detects PC1/3 protein at cytosol and secreted on mouse intestine by immunohistochemical analysis. Sample: Paraffin-embedded mouse intestine. PCSK1 Polyclonal Antibody (Product # PA5-29832) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-29832
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human PC1/3. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.52 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2547306
Product Specific Information
Recommended positive controls: HepG2, HCT116.
Predicted reactivity: Mouse (99%), Rat (100%), Zebrafish (93%), Pig (100%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. The use of alternate polyadenylation sites has been found for this gene. Multiple alternatively spliced transcript variants have been described for this gene but their full length nature is not known.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 3.4.21.93; Furin homolog; NEC 1; Neuroendocrine convertase 1; PC1; PC3; Prohormone convertase 1; prohormone convertase 1/3; prohormone convertase 3; Propeptide-processing protease; Proprotein convertase 1
Gene Aliases: Att-1; BMIQ12; Nec-1; NEC1; PC1; PC3; PCSK1; Phpp-1; SPC3
UniProt ID: (Human) P29120, (Mouse) P63239
Entrez Gene ID: (Human) 5122, (Mouse) 18548
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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