Proteintech

PD-1/CD279 Polyclonal Antibody

PD-1/CD279 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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PD-1/CD279 Antibody (18106-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human angioimmunoblastic T-cell lymphoma tissue slide using 18106-1-AP (PD-1/CD279 Antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

PD-1/CD279 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

PD-1/CD279 Antibody in Western Blot (WB)

PD-1/CD279 Antibody in Flow Cytometry (Flow)

PD-1/CD279 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

18106-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:300-1:1,000

View 23 publications 23 publications

Immunohistochemistry (IHC)

View 34 publications 34 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:400-1:1,600

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 15 publications 15 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PD-1/CD279 Fusion Protein Ag12470 (1-288 aa encoded by BC074740)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MQIPQAPWP VVWAVLQLGW RPGWFLDSPD RPWNPPTFSP ALLVVTEGDN ATFTCSFSNT SESFVLNWYR MSPSNQTDKL AAFPEDRSQP GQDCRFRVTQ LPNGRDFHMS VVRARRNDSG TYLCGAISLA PKAQIKESLR AELRVTERRA EVPTAHPSPS PRPAGQFQTL VVGVVGGLLG SLVLLVWVLA VICSRAARGT IGARRTGQPL KEDPSAVPVF SVDYGELDFQ WREKTPEPPV PCVPEQTEYA TIVFPSGMGT SSPARRGSAD GPRSAQPLRP EDGHCSWPL (1-288 aa encoded by BC074740 )

Target Information

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Molecular therapy : the journal of the American Society of Gene Therapy

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Wed Jan 04 00:00:00 UTC 2023

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Synergy of nanodiamond-doxorubicin conjugates and PD-L1 blockade effectively turns tumor-associated macrophages against tumor cells.

Journal of nanobiotechnology

Xu HZ,Li TF,Wang C,Ma Y,Liu Y,Zheng MY,Liu ZJ,Chen JB,Li K,Sun SK,Komatsu N,Xu YH,Zhao L,Chen X

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Synergy of nanodiamond-doxorubicin conjugates and PD-L1 blockade effectively turns tumor-associated macrophages against tumor cells.

Journal of nanobiotechnology

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Synergy of nanodiamond-doxorubicin conjugates and PD-L1 blockade effectively turns tumor-associated macrophages against tumor cells.

Journal of nanobiotechnology

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Synergy of nanodiamond-doxorubicin conjugates and PD-L1 blockade effectively turns tumor-associated macrophages against tumor cells.

Journal of nanobiotechnology

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Mon Sep 06 00:00:00 UTC 2021

Synergy of nanodiamond-doxorubicin conjugates and PD-L1 blockade effectively turns tumor-associated macrophages against tumor cells.

Journal of nanobiotechnology

Xu HZ,Li TF,Wang C,Ma Y,Liu Y,Zheng MY,Liu ZJ,Chen JB,Li K,Sun SK,Komatsu N,Xu YH,Zhao L,Chen X

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Altered peripheral helper T cells in peripheral blood and muscle tissue of the patients with dermatomyositis.

Clinical and experimental medicine

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Programmed cell death protein 1 promotes hepatitis B virus transmission through the regulation of ERK1/2-mediated trophoblasts differentiation.

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Yang J,Liu J,Sheng M,Zhang X,Liu M

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Isolation of DNA Aptamer Targeting PD-1 with an Antitumor Immunotherapy Effect.

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Gao T,Pei R

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Intratumoral administration of the Toll-like receptor 7/8 agonist 3M-052 enhances interferon-driven tumor immunogenicity and suppresses metastatic spread in preclinical triple-negative breast cancer.

Clinical & translational immunology

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BTLA Expression in Stage I-III Non-Small-Cell Lung Cancer and Its Correlation with PD-1/PD-L1 and Clinical Outcomes.

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Li X,Xu Z,Cui G,Yu L,Zhang X

Tue Apr 12 00:00:00 UTC 2022

Programmed Cell Death-1: Programmed Cell Death-Ligand 1 Interaction Protects Human Cardiomyocytes Against T-Cell Mediated Inflammation and Apoptosis Response In Vitro.

International journal of molecular sciences

Tay WT,Fang YH,Beh ST,Liu YW,Hsu LW,Yen CJ,Liu PY

Tue Mar 31 00:00:00 UTC 2020

Promoting the activation of T cells with glycopolymer-modified dendritic cells by enhancing cell interactions.

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Yu L,Feng R,Zhu L,Hao Q,Chu J,Gu Y,Luo Y,Zhang Z,Chen G,Chen H

Sun Nov 01 00:00:00 UTC 2020

Synergistic anti-liver cancer effects of curcumin and total ginsenosides.

World journal of gastrointestinal oncology

Deng Z,Xu XY,Yunita F,Zhou Q,Wu YR,Hu YX,Wang ZQ,Tian XF

Thu Oct 15 00:00:00 UTC 2020

Molecular subtyping reveals immune alterations in IDH wild-type lower-grade diffuse glioma.

The Journal of pathology

Wu F,Li GZ,Liu HJ,Zhao Z,Chai RC,Liu YQ,Jiang HY,Zhai Y,Feng YM,Li RP,Zhang W

Wed Jul 01 00:00:00 UTC 2020

New insight on the correlation of metabolic status on ¹⁸F-FDG PET/CT with immune marker expression in patients with non-small cell lung cancer.

European journal of nuclear medicine and molecular imaging

Wang Y,Zhao N,Wu Z,Pan N,Shen X,Liu T,Wei F,You J,Xu W,Ren X

Fri May 01 00:00:00 UTC 2020

Efficient Gene Silencing by Adenine Base Editor-Mediated Start Codon Mutation.

Molecular therapy : the journal of the American Society of Gene Therapy

Wang X,Liu Z,Li G,Dang L,Huang S,He L,Ma Y,Li C,Liu M,Yang G,Huang X,Zhou F,Ma X

Wed Feb 05 00:00:00 UTC 2020

Direct therapeutic targeting of immune checkpoint PD-1 in pancreatic cancer.

British journal of cancer

Gao M,Lin M,Moffitt RA,Salazar MA,Park J,Vacirca J,Huang C,Shroyer KR,Choi M,Georgakis GV,Sasson AR,Talamini MA,Kim J

Tue Jan 01 00:00:00 UTC 2019

Direct therapeutic targeting of immune checkpoint PD-1 in pancreatic cancer.

British journal of cancer

Gao M,Lin M,Moffitt RA,Salazar MA,Park J,Vacirca J,Huang C,Shroyer KR,Choi M,Georgakis GV,Sasson AR,Talamini MA,Kim J

Tue Jan 01 00:00:00 UTC 2019

Expression of PD-1/PD-L1 in head and neck squamous cell carcinoma and its clinical significance.

The International journal of biological markers

Chen SW,Li SH,Shi DB,Jiang WM,Song M,Yang AK,Li YD,Bei JX,Chen WK,Zhang Q

Sun Dec 01 00:00:00 UTC 2019

Tumor inherent interferon regulators as biomarkers of long-term chemotherapeutic response in TNBC.

NPJ precision oncology

Brockwell NK,Rautela J,Owen KL,Gearing LJ,Deb S,Harvey K,Spurling A,Zanker D,Chan CL,Cumming HE,Deng N,Zakhour JM,Duivenvoorden HM,Robinson T,Harris M,White M,Fox J,Ooi C,Kumar B,Thomson J,Potasz N,Swarbrick A,Hertzog PJ,Molloy TJ,Toole SO,Ganju V,Parker BS

Fri Jul 19 00:00:00 UTC 2024

Bifidobacterium infantis Induces Protective Colonic PD-L1 and Foxp3 Regulatory T Cells in an Acute Murine Experimental Model of Inflammatory Bowel Disease.

Gut and liver

Zhou L,Liu D,Xie Y,Yao X,Li Y

Fri Mar 15 00:00:00 UTC 2019

Estradiol Attenuates the Severity of Primary Toxoplasma gondii Infection-Induced Adverse Pregnancy Outcomes Through the Regulation of Tregs in a Dose-Dependent Manner.

Frontiers in immunology

Qiu J,Zhang R,Xie Y,Wang L,Ge K,Chen H,Liu X,Wu J,Wang Y

Fri Jul 26 00:00:00 UTC 2019

Estradiol Attenuates the Severity of Primary Toxoplasma gondii Infection-Induced Adverse Pregnancy Outcomes Through the Regulation of Tregs in a Dose-Dependent Manner.

Frontiers in immunology

Qiu J,Zhang R,Xie Y,Wang L,Ge K,Chen H,Liu X,Wu J,Wang Y

Fri Jul 26 00:00:00 UTC 2019

PD-1/PD-L1 Axis, Rather Than High-Mobility Group Alarmins or CD8+ Tumor-Infiltrating Lymphocytes, Is Associated With Survival in Head and Neck Squamous Cell Carcinoma Patients Who Received Surgical Resection.

Frontiers in oncology

Yang F,Zeng Z,Li J,Zheng Y,Wei F,Ren X

Thu Oct 01 00:00:00 UTC 2020

Frontiers in oncology

Yang F,Zeng Z,Li J,Zheng Y,Wei F,Ren X

Thu Oct 01 00:00:00 UTC 2020

Co-expression of AFAP1-AS1 and PD-1 predicts poor prognosis in nasopharyngeal carcinoma.

Oncotarget

Tang Y,He Y,Shi L,Yang L,Wang J,Lian Y,Fan C,Zhang P,Guo C,Zhang S,Gong Z,Li X,Xiong F,Li X,Li Y,Li G,Xiong W,Zeng Z

Tue Jun 13 00:00:00 UTC 2017

Immunological markers predict the prognosis of patients with squamous non-small cell lung cancer.

Immunologic research

Jiang L,Zhao Z,Jiang S,Lin Y,Yang H,Xie Z,Lin Y,Long H

Wed Jul 01 00:00:00 UTC 2015

Immunological markers predict the prognosis of patients with squamous non-small cell lung cancer.

Immunologic research

Jiang L,Zhao Z,Jiang S,Lin Y,Yang H,Xie Z,Lin Y,Long H

Wed Jul 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: CD279; hPD1; programmed cell death 1 protein; Programmed cell death protein 1; Protein PD-1; Protein PD1; sCD279; soluble CD279; systemic lupus erythematosus susceptibility 2

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Gene Aliases: CD279; hPD-1; hPD-l; hSLE1; PD-1; PD1; PDCD1; SLEB2

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UniProt ID: (Human) Q15116

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Entrez Gene ID: (Human) 5133

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Function(s)

signal transducer activity protein binding

Process(es)

negative regulation of tolerance induction apoptotic process humoral immune response signal transduction multicellular organism development T cell costimulation negative regulation of apoptotic process positive regulation of T cell apoptotic process

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PD-1/CD279 Polyclonal Antibody

PD-1/CD279 Antibody (18106-1-AP) in IHC (P)

Product Details

18106-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

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Purification

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Bioinformatics

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