Product References
Incorporation of a TGF-β2-inhibiting oligodeoxynucleotide molecular adjuvant into a tumor cell lysate vaccine to enhance antiglioma immunity in mice.
Frontiers in immunology
Tu L,Wang Z,Yang L,Sun X,Yao Y,Zhang P,Zhang X,Wang L,Yu Y,Yang M
PA5-20343 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that TIO3 is a promising adjuvant for enhancing TCL-based vaccines to produce a more vigorous and long-lasting antitumor response by interfering with TGF-ß2 expression.
Tue Feb 14 00:00:00 UTC 2023
Incorporation of a TGF-β2-inhibiting oligodeoxynucleotide molecular adjuvant into a tumor cell lysate vaccine to enhance antiglioma immunity in mice.
Frontiers in immunology
Tu L,Wang Z,Yang L,Sun X,Yao Y,Zhang P,Zhang X,Wang L,Yu Y,Yang M
PA5-20343 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that TIO3 is a promising adjuvant for enhancing TCL-based vaccines to produce a more vigorous and long-lasting antitumor response by interfering with TGF-ß2 expression.
Tue Feb 14 00:00:00 UTC 2023
Upregulation of programmed death ligand-1 in tumor-associated macrophages affects chemotherapeutic response in ovarian cancer cells.
PloS one
Jang YS,Kim TW,Ryu JS,Kong HJ,Jang SH,Nam GH,Kim JH,Jeon S
Published figure using PD-L1 polyclonal antibody (Product # PA5-20343) in Immunohistochemistry
Mon Feb 13 00:00:00 UTC 2023
Upregulation of programmed death ligand-1 in tumor-associated macrophages affects chemotherapeutic response in ovarian cancer cells.
PloS one
Jang YS,Kim TW,Ryu JS,Kong HJ,Jang SH,Nam GH,Kim JH,Jeon S
Published figure using PD-L1 polyclonal antibody (Product # PA5-20343) in Immunohistochemistry
Mon Feb 13 00:00:00 UTC 2023
Upregulation of programmed death ligand-1 in tumor-associated macrophages affects chemotherapeutic response in ovarian cancer cells.
PloS one
Jang YS,Kim TW,Ryu JS,Kong HJ,Jang SH,Nam GH,Kim JH,Jeon S
Published figure using PD-L1 polyclonal antibody (Product # PA5-20343) in Immunohistochemistry
Mon Feb 13 00:00:00 UTC 2023
Upregulation of programmed death ligand-1 in tumor-associated macrophages affects chemotherapeutic response in ovarian cancer cells.
PloS one
Jang YS,Kim TW,Ryu JS,Kong HJ,Jang SH,Nam GH,Kim JH,Jeon S
Published figure using PD-L1 polyclonal antibody (Product # PA5-20343) in Immunohistochemistry
Mon Feb 13 00:00:00 UTC 2023
FOXO3-dependent suppression of PD-L1 promotes anticancer immune responses via activation of natural killer cells.
American journal of cancer research
Chung YM,Tsai WB,Khan PP,Ma J,Berek JS,Larrick JW,Hu MC
PA5-20343 was used in Immunocytochemistry to explore how low-dose pharmacological immunoactivators notably downregulate programmed death-1 and upregulate FOX03 expression in various human and murine cancer cell lines.
Mon May 13 00:00:00 UTC 2024
Immunorthodontics: PD-L1, a Novel Immunomodulator in Cementoblasts, Is Regulated by HIF-1α under Hypoxia.
Cells
Yong J,Gröger S,von Bremen J,Meyle J,Ruf S
PA5-20343 was used in Western Blot, Immunocytochemistry, Flow Cytometry to conclude that combined HIF-1α/PD-L1 inhibition could be of possible therapeutic relevance for OIIRR prevention.
Sat Jul 30 00:00:00 UTC 2022
Immunorthodontics: PD-L1, a Novel Immunomodulator in Cementoblasts, Is Regulated by HIF-1α under Hypoxia.
Cells
Yong J,Gröger S,von Bremen J,Meyle J,Ruf S
PA5-20343 was used in Western Blot, Immunocytochemistry, Flow Cytometry to conclude that combined HIF-1α/PD-L1 inhibition could be of possible therapeutic relevance for OIIRR prevention.
Sat Jul 30 00:00:00 UTC 2022
Immunorthodontics: PD-L1, a Novel Immunomodulator in Cementoblasts, Is Regulated by HIF-1α under Hypoxia.
Cells
Yong J,Gröger S,von Bremen J,Meyle J,Ruf S
PA5-20343 was used in Western Blot, Immunocytochemistry, Flow Cytometry to conclude that combined HIF-1α/PD-L1 inhibition could be of possible therapeutic relevance for OIIRR prevention.
Sat Jul 30 00:00:00 UTC 2022
Immunorthodontics: PD-L1, a Novel Immunomodulator in Cementoblasts, Is Regulated by HIF-1α under Hypoxia.
Cells
Yong J,Gröger S,von Bremen J,Meyle J,Ruf S
PA5-20343 was used in Western Blot, Immunocytochemistry, Flow Cytometry to conclude that combined HIF-1α/PD-L1 inhibition could be of possible therapeutic relevance for OIIRR prevention.
Sat Jul 30 00:00:00 UTC 2022
Immunorthodontics: PD-L1, a Novel Immunomodulator in Cementoblasts, Is Regulated by HIF-1α under Hypoxia.
Cells
Yong J,Gröger S,von Bremen J,Meyle J,Ruf S
PA5-20343 was used in Western Blot, Immunocytochemistry, Flow Cytometry to conclude that combined HIF-1α/PD-L1 inhibition could be of possible therapeutic relevance for OIIRR prevention.
Sat Jul 30 00:00:00 UTC 2022
Immunorthodontics: PD-L1, a Novel Immunomodulator in Cementoblasts, Is Regulated by HIF-1α under Hypoxia.
Cells
Yong J,Gröger S,von Bremen J,Meyle J,Ruf S
PA5-20343 was used in Western Blot, Immunocytochemistry, Flow Cytometry to conclude that combined HIF-1α/PD-L1 inhibition could be of possible therapeutic relevance for OIIRR prevention.
Sat Jul 30 00:00:00 UTC 2022
HE4 Overexpression by Ovarian Cancer Promotes a Suppressive Tumor Immune Microenvironment and Enhanced Tumor and Macrophage PD-L1 Expression.
Journal of immunology (Baltimore, Md. : 1950)
Rowswell-Turner RB,Singh RK,Urh A,Yano N,Kim KK,Khazan N,Pandita R,Sivagnanalingam U,Hovanesian V,James NE,Ribeiro JR,Kadambi S,Linehan DC,Moore RG
PA5-20343 was used in Flow cytometry/Cell sorting to identify HE4 as a mediator of tumor-immune suppression in ovarian cancer, highlighting this molecule as a potential therapeutic target for the treatment of this devastating disease.
Sat May 15 00:00:00 UTC 2021
Preclinical Pharmacokinetics and Dosimetry of an 89Zr Labelled Anti-PDL1 in an Orthotopic Lung Cancer Murine Model.
Frontiers in medicine
Krache A,Fontan C,Pestourie C,Bardiès M,Bouvet Y,Payoux P,Chatelut E,White-Koning M,Salabert AS
PA5-20343 was used in Immunohistochemistry to conclude that the predicted dosimetry was similar or lower than other antibodies radiolabelled with zirconium-89 for immunoPET imaging.
Sun May 01 00:00:00 UTC 2022
Preclinical Pharmacokinetics and Dosimetry of an 89Zr Labelled Anti-PDL1 in an Orthotopic Lung Cancer Murine Model.
Frontiers in medicine
Krache A,Fontan C,Pestourie C,Bardiès M,Bouvet Y,Payoux P,Chatelut E,White-Koning M,Salabert AS
PA5-20343 was used in Immunohistochemistry to conclude that the predicted dosimetry was similar or lower than other antibodies radiolabelled with zirconium-89 for immunoPET imaging.
Sun May 01 00:00:00 UTC 2022
Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model.
Oncotarget
Zaidi AH,Kelly RJ,Gorbunova A,Omstead AN,Salvitti MS,Zheng P,Kosovec JE,Lee S,Ayazi S,Babar L,Finley GG,Goel A,Jobe BA
Published figure using PD-L1 polyclonal antibody (Product # PA5-20343) in Immunohistochemistry
Tue Feb 16 00:00:00 UTC 2021
Overcoming PD-1 Inhibitor Resistance with a Monoclonal Antibody to Secreted Frizzled-Related Protein 2 in Metastatic Osteosarcoma.
Cancers
Nasarre P,Garcia DI,Siegel JB,Bonilla IV,Mukherjee R,Hilliard E,Chakraborty P,Nasarre C,Yustein JT,Lang M,Jaffa AA,Mehrotra S,Klauber-DeMore N
PA5-20343 was used in Western Blot to investigate the function of Secreted frizzled-related protein 2 (SFRP2) on immunity when blocked using a humanized monoclonal antibody in Metastatic Osteosarcoma.
Sun May 30 00:00:00 UTC 2021
Overcoming PD-1 Inhibitor Resistance with a Monoclonal Antibody to Secreted Frizzled-Related Protein 2 in Metastatic Osteosarcoma.
Cancers
Nasarre P,Garcia DI,Siegel JB,Bonilla IV,Mukherjee R,Hilliard E,Chakraborty P,Nasarre C,Yustein JT,Lang M,Jaffa AA,Mehrotra S,Klauber-DeMore N
PA5-20343 was used in Western Blot to investigate the function of Secreted frizzled-related protein 2 (SFRP2) on immunity when blocked using a humanized monoclonal antibody in Metastatic Osteosarcoma.
Sun May 30 00:00:00 UTC 2021
Expression of immune checkpoint PD-1 in non-small cell lung cancer is associated with tumor cell DNA-dependent protein kinase.
Molecular and clinical oncology
Saar M,Narits J,Mägi L,Aaspõllu H,Vapper A,Kase M,Minajeva A,Vooder T,Tamm H,Buldakov M,Lavõgina D,Jaal J
PA5-20343 was used in Immunohistochemistry to demonstrate a significant positive correlation between the PD-1/PD-L1 axis and tumor cell DNA-PK expression in patients with NSCLC.
Fri Oct 01 00:00:00 UTC 2021
Expression of immune checkpoint PD-1 in non-small cell lung cancer is associated with tumor cell DNA-dependent protein kinase.
Molecular and clinical oncology
Saar M,Narits J,Mägi L,Aaspõllu H,Vapper A,Kase M,Minajeva A,Vooder T,Tamm H,Buldakov M,Lavõgina D,Jaal J
PA5-20343 was used in Immunohistochemistry to demonstrate a significant positive correlation between the PD-1/PD-L1 axis and tumor cell DNA-PK expression in patients with NSCLC.
Fri Oct 01 00:00:00 UTC 2021
In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target.
Cell
Wang X,Tokheim C,Gu SS,Wang B,Tang Q,Li Y,Traugh N,Zeng Z,Zhang Y,Li Z,Zhang B,Fu J,Xiao T,Li W,Meyer CA,Chu J,Jiang P,Cejas P,Lim K,Long H,Brown M,Liu XS
PA5-20343 was used in Functional, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to implicate Cop1 as a target for improving cancer immunotherapy efficacy in TNBC by regulating chemokine secretion and macrophage infiltration in the tumor microenvironment.
Thu Oct 14 00:00:00 UTC 2021
CMTM6 drives cisplatin resistance by regulating Wnt signaling through the ENO-1/AKT/GSK3β axis.
JCI insight
Mohapatra P,Shriwas O,Mohanty S,Ghosh A,Smita S,Kaushik SR,Arya R,Rath R,Das Majumdar SK,Muduly DK,Raghav SK,Nanda RK,Dash R
PA5-20343 was used in Immunohistochemistry (Paraffin) to to show that, as CMTM6 facilitates tumor cells for immune evasion and mediates cisplatin resistance, it could be a promising therapeutic target for treating therapy-resistant OSCC.
Mon Feb 22 00:00:00 UTC 2021
CMTM6 drives cisplatin resistance by regulating Wnt signaling through the ENO-1/AKT/GSK3β axis.
JCI insight
Mohapatra P,Shriwas O,Mohanty S,Ghosh A,Smita S,Kaushik SR,Arya R,Rath R,Das Majumdar SK,Muduly DK,Raghav SK,Nanda RK,Dash R
PA5-20343 was used in Immunohistochemistry (Paraffin) to to show that, as CMTM6 facilitates tumor cells for immune evasion and mediates cisplatin resistance, it could be a promising therapeutic target for treating therapy-resistant OSCC.
Mon Feb 22 00:00:00 UTC 2021
Novel Insights into the Antagonistic Effects of Losartan against Angiotensin II/AGTR1 Signaling in Glioblastoma Cells.
Cancers
Panza S,Malivindi R,Caruso A,Russo U,Giordano F,Győrffy B,Gelsomino L,De Amicis F,Barone I,Conforti FL,Giordano C,Bonofiglio D,Catalano S,Andò S
PA5-20343 was used in Immunohistochemistry to demonstrate how Ang II treatment in glioblastoma cells increases programmed death-ligand 1 (PD-L1) expression reversed by combined exposure to Losartan (LOS) in vitro and in vivo.
Fri Sep 10 00:00:00 UTC 2021
Programmed Death Ligand 1-Expressing Classical Dendritic Cells MitigateHelicobacter-Induced Gastritis.
Cellular and molecular gastroenterology and hepatology
Go DM,Lee SH,Lee SH,Woo SH,Kim K,Kim K,Park KS,Park JH,Ha SJ,Kim WH,Choi JH,Kim DY
PA5-20343 was used in Immunohistochemistry to conclude that the PD-1/PD-L1 pathway may be responsible for the immune modulatory function of gastric DCs that protects the gastric mucosa from Helicobacter-induced inflammation, but allows persistent Helicobacter colonization.
Thu Jan 27 00:00:00 UTC 2022
Knockdown of Leptin Receptor Affects Macrophage Phenotype in the Tumor Microenvironment Inhibiting Breast Cancer Growth and Progression.
Cancers
Gelsomino L,Naimo GD,Malivindi R,Augimeri G,Panza S,Giordano C,Barone I,Bonofiglio D,Mauro L,Catalano S,Andò S
PA5-20343 was used in Immunohistochemistry-immunofluorescence to evaluate how the tumour cell-macrophage interaction and breast cancer phenotype are affected by leptin receptor knockdown.
Mon Jul 27 00:00:00 UTC 2020
Knockdown of Leptin Receptor Affects Macrophage Phenotype in the Tumor Microenvironment Inhibiting Breast Cancer Growth and Progression.
Cancers
Gelsomino L,Naimo GD,Malivindi R,Augimeri G,Panza S,Giordano C,Barone I,Bonofiglio D,Mauro L,Catalano S,Andò S
PA5-20343 was used in Immunohistochemistry-immunofluorescence to evaluate how the tumour cell-macrophage interaction and breast cancer phenotype are affected by leptin receptor knockdown.
Mon Jul 27 00:00:00 UTC 2020
Knockdown of Leptin Receptor Affects Macrophage Phenotype in the Tumor Microenvironment Inhibiting Breast Cancer Growth and Progression.
Cancers
Gelsomino L,Naimo GD,Malivindi R,Augimeri G,Panza S,Giordano C,Barone I,Bonofiglio D,Mauro L,Catalano S,Andò S
PA5-20343 was used in Immunohistochemistry-immunofluorescence to evaluate how the tumour cell-macrophage interaction and breast cancer phenotype are affected by leptin receptor knockdown.
Mon Jul 27 00:00:00 UTC 2020
Immunotherapy via PD-L1-presenting biomaterials leads to long-term islet graft survival.
Science advances
Coronel MM,Martin KE,Hunckler MD,Barber G,O'Neill EB,Medina JD,Opri E,McClain CA,Batra L,Weaver JD,Lim HS,Qiu P,Botchwey EA,Yolcu ES,Shirwan H,García AJ
PA5-20343 was used in Western Blot to implement a synthetic biomaterial platform for the local delivery of a chimeric streptavidin/programmed cell death-1 (SA-PD-L1) protein to direct "reprogramming" of local immune responses to transplanted pancreatic islets.
Sat Aug 01 00:00:00 UTC 2020
Immunotherapy via PD-L1-presenting biomaterials leads to long-term islet graft survival.
Science advances
Coronel MM,Martin KE,Hunckler MD,Barber G,O'Neill EB,Medina JD,Opri E,McClain CA,Batra L,Weaver JD,Lim HS,Qiu P,Botchwey EA,Yolcu ES,Shirwan H,García AJ
PA5-20343 was used in Western Blot to implement a synthetic biomaterial platform for the local delivery of a chimeric streptavidin/programmed cell death-1 (SA-PD-L1) protein to direct "reprogramming" of local immune responses to transplanted pancreatic islets.
Sat Aug 01 00:00:00 UTC 2020
Targeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+ T cell mediated immune response.
Oncoimmunology
Song M,Wang C,Wang H,Zhang T,Li J,Benezra R,Chouchane L,Sun YH,Cui XG,Ma X
PA5-20343 was used in Immunohistochemistry to investigate UBR5-mediated signalling in breast cancer growth and metastasis.
Wed Jul 28 00:00:00 UTC 2021
Targeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+ T cell mediated immune response.
Oncoimmunology
Song M,Wang C,Wang H,Zhang T,Li J,Benezra R,Chouchane L,Sun YH,Cui XG,Ma X
PA5-20343 was used in Immunohistochemistry to investigate UBR5-mediated signalling in breast cancer growth and metastasis.
Wed Jul 28 00:00:00 UTC 2021
Expression of circular RNA CDR1‑AS in colon cancer cells increases cell surface PD‑L1 protein levels.
Oncology reports
Tanaka E,Miyakawa Y,Kishikawa T,Seimiya T,Iwata T,Funato K,Odawara N,Sekiba K,Yamagami M,Suzuki T,Ishibashi R,Otsuka M,Koike K
PA5-20343 was used in Immunohistochemistry, Flow Cytometry to study the biological functional of CDR1-AS RNA and its association with malignant behavior of cancer cells.
Tue Oct 01 00:00:00 UTC 2019
Expression of circular RNA CDR1‑AS in colon cancer cells increases cell surface PD‑L1 protein levels.
Oncology reports
Tanaka E,Miyakawa Y,Kishikawa T,Seimiya T,Iwata T,Funato K,Odawara N,Sekiba K,Yamagami M,Suzuki T,Ishibashi R,Otsuka M,Koike K
PA5-20343 was used in Immunohistochemistry, Flow Cytometry to study the biological functional of CDR1-AS RNA and its association with malignant behavior of cancer cells.
Tue Oct 01 00:00:00 UTC 2019
Immunohistochemical Features of Epithelial-Mesenchymal Transition in Feline Oral Squamous Cell Carcinoma.
Veterinary pathology
Harris K,Gelberg HB,Kiupel M,Helfand SC
PA5-20343 was used in Immunohistochemistry to identify proteins associated with EMT in FOSCC. This study documents protein expression patterns in 10 FOSCC biopsies and 3 FOSCC cell lines (SCCF1, SCCF2, SCCF3), compatible with an EMT phenotype.
Fri Nov 01 00:00:00 UTC 2019
PDL1 And LDHA act as ceRNAs in triple negative breast cancer by regulating miR-34a.
Journal of experimental & clinical cancer research : CR
Huang X,Xie X,Wang H,Xiao X,Yang L,Tian Z,Guo X,Zhang L,Tang H,Xie X
PA5-20343 was used in Western Blotting to provide a novel therapeutic strategy for triple negative breast cancer by exploring the function of PDL1 And LDHA as competitive endogenous RNAs.
Fri Sep 15 00:00:00 UTC 2017
PDL1 And LDHA act as ceRNAs in triple negative breast cancer by regulating miR-34a.
Journal of experimental & clinical cancer research : CR
Huang X,Xie X,Wang H,Xiao X,Yang L,Tian Z,Guo X,Zhang L,Tang H,Xie X
PA5-20343 was used in Western Blotting to provide a novel therapeutic strategy for triple negative breast cancer by exploring the function of PDL1 And LDHA as competitive endogenous RNAs.
Fri Sep 15 00:00:00 UTC 2017
Roles of programmed death protein 1/programmed death-ligand 1 in secondary brain injury after intracerebral hemorrhage in rats: selective modulation of microglia polarization to anti-inflammatory phenotype.
Journal of neuroinflammation
Wu J,Sun L,Li H,Shen H,Zhai W,Yu Z,Chen G
PA520343 was used in immunocytochemistry, immunoprecipitation, and western blot to assess the critical role of programmed death protein 1/programmed death-ligand 1 in the polarization of microglia during intracerebral hemorrhage-induced secondary brain injury
Tue Feb 14 00:00:00 UTC 2017
Roles of programmed death protein 1/programmed death-ligand 1 in secondary brain injury after intracerebral hemorrhage in rats: selective modulation of microglia polarization to anti-inflammatory phenotype.
Journal of neuroinflammation
Wu J,Sun L,Li H,Shen H,Zhai W,Yu Z,Chen G
PA520343 was used in immunocytochemistry, immunoprecipitation, and western blot to assess the critical role of programmed death protein 1/programmed death-ligand 1 in the polarization of microglia during intracerebral hemorrhage-induced secondary brain injury
Tue Feb 14 00:00:00 UTC 2017
Roles of programmed death protein 1/programmed death-ligand 1 in secondary brain injury after intracerebral hemorrhage in rats: selective modulation of microglia polarization to anti-inflammatory phenotype.
Journal of neuroinflammation
Wu J,Sun L,Li H,Shen H,Zhai W,Yu Z,Chen G
PA520343 was used in immunocytochemistry, immunoprecipitation, and western blot to assess the critical role of programmed death protein 1/programmed death-ligand 1 in the polarization of microglia during intracerebral hemorrhage-induced secondary brain injury
Tue Feb 14 00:00:00 UTC 2017
