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Invitrogen
PDCD10 Polyclonal Antibody
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FIGURE: 1 / 1
PDCD10 Antibody (PA5-90441) in WB
Western blot analysis of PDCD10 in extracts from normal (control) and PDCD10 knockout (KO) HeLa cells. Samples were incubated with PDCD10 Polyclonal antibody (Product # PA5-90441) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 15s.
Product Details
PA5-90441
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-212 of human PDCD10 (NP_0091482)
Conjugate
Form
Liquid
Concentration
0.53 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2806076
Product Specific Information
Immunogen sequence: MRMTMEEMKN EAETTSMVSM PLYAVMYPVF NELERVNLSA AQTLRAAFIK AEKENPGLTQ DIIMKILEKK SVEVNFTESL LRMAADDVEE YMIERPEPEF QDLNEKARAL KQILSKIPDE INDRVRFLQT IKDIASAIKE LLDTVNNVFK KYQYQNRRAL EHQKKEFVKY SKSFSDTLKT YFKDGKAINV FVSANRLIHQ TNLILQTFKT VA; Positive Samples: A-431, HepG2, Jurkat, MCF7, Mouse thymus, Mouse brain; Cellular Location: Cell membrane, Cytoplasm, Cytoplasmic side, Golgi apparatus membrane, Peripheral membrane protein
Target Information
This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: apoptosis-related protein 15; Cerebral cavernous malformations 3 protein; MGC1212; MGC24477; PDCD 10; Programmed cell death protein 10; TF-1 cell apoptosis-related protein 15
Gene Aliases: 2410003B13Rik; CCM3; PDCD10; Tfa15; TFAR15
UniProt ID: (Human) Q9BUL8, (Rat) Q6NX65, (Mouse) Q8VE70
Entrez Gene ID: (Human) 11235, (Rat) 494345, (Mouse) 56426
angiogenesis
apoptotic process
positive regulation of cell proliferation
positive regulation of gene expression
negative regulation of gene expression
positive regulation of cell migration
positive regulation of stress-activated MAPK cascade
positive regulation of peptidyl-serine phosphorylation
regulation of Rho protein signal transduction
intrinsic apoptotic signaling pathway in response to hydrogen peroxide
response to hydrogen peroxide
negative regulation of apoptotic process
stress fiber assembly
positive regulation of MAP kinase activity
wound healing, spreading of cells
positive regulation of Notch signaling pathway
protein stabilization
establishment of Golgi localization
positive regulation of protein serine/threonine kinase activity
negative regulation of cell migration involved in sprouting angiogenesis
Golgi reassembly
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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