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Immunogen sequence: MAAVLKPVLL GLRDAPVHGS PTGPGAWTAS KLGGIPDALP TVAAPRPVCQ RCGQPLALVV QVYCPLEGSP FHRLLHVFAC ACPGCSTGGA RSWKVFRSQC LQVPEREAQD AQKQGNSLAA EDWCEGADDW GSDTEEGPSP QFTLDFGNDA SSAKDVDWTA RLQDLRLQDA VLGAAHPVPP GLPLFLPYYI CVADEDDYRD FVNLDHAHSL LRDYQQREGI AMDQLLSQSL PNDGDEKYEK TIIKSGDQTF YKFMKRIAAC QEQILRYSWS GEPLFLTCPT SEVTELPACS QCGGQRIFEF QLMPALVSML KSANLGLSVE FGTILVYTCE KSCWPPNHQT PMEEFCIIQE DPDELLFK; Positive Samples: HeLa, MCF7, SKOV3, BT-474, Mouse testis, Mouse brain, Mouse heart
Over expression of PDCD2L attenutates TNF-alpha release in Daudi cells. PDCD2L over-expression restrained proliferation of HEK293T cells. DNA/flow cytometry analysis showed that the over-expression of PDCD2L severely delays cell cycle progression at S phase. These all suggest that PDCD2L might play a role in apoptosis.
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Protein Aliases: MGC13096; programmed cell death 2-like; Programmed cell death protein 2-like
Gene Aliases: 6030457N17Rik; PDCD2L; RGD1308249
UniProt ID: (Human) Q9BRP1, (Mouse) Q8C5N5
Entrez Gene ID: (Human) 84306, (Rat) 689637, (Mouse) 68079
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