Proteintech

PDCD6 Polyclonal Antibody

PDCD6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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PDCD6 Antibody (12303-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using 12303-1-AP ( PDCD6 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

PDCD6 Antibody in Immunoprecipitation (IP)

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Product Details

12303-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 15 publications 15 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 7 publications 7 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PDCD6 Fusion Protein Ag2949 (1-191 aa encoded by BC012384)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAAYSYRPG PGAGPGPAAG AALPDQSFLW NVFQRVDKDR SGVISDTELQ QALSNGTWTP FNPVTVRSII SMFDRENKAG VNFSEFTGVW KYITDWQNVF RTYDRDNSGM IDKNELKQAL SGFGYRLSDQ FHDILIRKFD RQGRGQIAFD DFIQGCIVLQ RLTDIFRRYD TDQDGWIQVS YEQYLSMVFS IV (1-191 aa encoded by BC012384)

Target Information

An increased intracellular Ca2+ concentration induces apoptotic cell death. Transiently elevated Ca2+ concentrations are required for glucocorticoid-mediated and T cell receptor-mediated pathways, leading to T cell apoptosis. ALG-2 (for apoptosis-linked gene 2) is a Ca2+ -binding protein that participates in regulatory events occuring late in the apoptotic program and where several death signals converge. ALG-2 is a protein expressed in normal brain, and to a greater extent in ischemic brain. The ALG-2 protein contains five EF-hand-like motifs and shares homology with members of the penta EF-hand family, which includes Calpain small subunits sorcin and Grancalcin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Analysis of Dysferlin Direct Interactions with Putative Repair Proteins Links Apoptotic Signaling to Ca²⁺ Elevation via PDCD6 and FKBP8.

International journal of molecular sciences

Drescher DG,Drescher MJ,Selvakumar D,Annam NP

Tue Feb 28 00:00:00 UTC 2023

PDCD6 Promotes Hepatocellular Carcinoma Cell Proliferation and Metastasis through the AKT/GSK3β/β-catenin Pathway.

Biomedical and environmental sciences : BES

Wen SY,Liu YT,Wei BY,Ma JQ,Chen YY

Mon Mar 20 00:00:00 UTC 2023

Giant worm-shaped ESCRT scaffolds surround actin-independent integrin clusters.

The Journal of cell biology

Stempels FC,Jiang M,Warner HM,Moser ML,Janssens MH,Maassen S,Nelen IH,de Boer R,Jiemy WF,Knight D,Selley J,O'Cualain R,Baranov MV,Burgers TCQ,Sansevrino R,Milovanovic D,Heeringa P,Jones MC,Vlijm R,Ter Beest M,van den Bogaart G

Mon Jul 03 00:00:00 UTC 2023

Lysosomal swelling and lysis mediate delivery of C3 toxins to their cytoplasmic targets.

Molecular microbiology

Turner M,Plumb J,Merrill AR,Grinstein S,Westman J

Thu Jun 01 00:00:00 UTC 2023

MAT2A facilitates PDCD6 methylation and promotes cell growth under glucose deprivation in cervical cancer.

Cell death discovery

Luo H,Song Y,Zhang JA,Liu Y,Chen F,Wang Z,Zhu X

Fri Apr 08 00:00:00 UTC 2022

MAT2A facilitates PDCD6 methylation and promotes cell growth under glucose deprivation in cervical cancer.

Cell death discovery

Luo H,Song Y,Zhang JA,Liu Y,Chen F,Wang Z,Zhu X

Fri Apr 08 00:00:00 UTC 2022

Interplay in neural functions of cell adhesion molecule close homolog of L1 (CHL1) and Programmed Cell Death 6 (PDCD6).

FASEB bioAdvances

Loers G,Theis T,Baixia Hao H,Kleene R,Arsha S,Samuel N,Arsha N,Young W,Schachner M

Sat Jan 01 00:00:00 UTC 2022

Interplay in neural functions of cell adhesion molecule close homolog of L1 (CHL1) and Programmed Cell Death 6 (PDCD6).

FASEB bioAdvances

Loers G,Theis T,Baixia Hao H,Kleene R,Arsha S,Samuel N,Arsha N,Young W,Schachner M

Sat Jan 01 00:00:00 UTC 2022

Interplay in neural functions of cell adhesion molecule close homolog of L1 (CHL1) and Programmed Cell Death 6 (PDCD6).

FASEB bioAdvances

Loers G,Theis T,Baixia Hao H,Kleene R,Arsha S,Samuel N,Arsha N,Young W,Schachner M

Sat Jan 01 00:00:00 UTC 2022

Co-adaptor driven assembly of a CUL3 E3 ligase complex.

Molecular cell

Akopian D,McGourty CA,Rapé M

Thu Feb 03 00:00:00 UTC 2022

Calcium-dependent ESCRT recruitment and lysosome exocytosis maintain epithelial integrity during Candida albicans invasion.

Cell reports

Westman J,Plumb J,Licht A,Yang M,Allert S,Naglik JR,Hube B,Grinstein S,Maxson ME

Tue Jan 04 00:00:00 UTC 2022

Calcium-dependent ESCRT recruitment and lysosome exocytosis maintain epithelial integrity during Candida albicans invasion.

Cell reports

Westman J,Plumb J,Licht A,Yang M,Allert S,Naglik JR,Hube B,Grinstein S,Maxson ME

Tue Jan 04 00:00:00 UTC 2022

Annexins A1 and A2 are recruited to larger lysosomal injuries independently of ESCRTs to promote repair.

FEBS letters

Yim WW,Yamamoto H,Mizushima N

Fri Apr 01 00:00:00 UTC 2022

An epithelial-mesenchymal transition-related 5-gene signature predicting the prognosis of hepatocellular carcinoma patients.

Cancer cell international

Zhu G,Xia H,Tang Q,Bi F

Fri Mar 12 00:00:00 UTC 2021

Circular RNA Calm4 Regulates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cells Pyroptosis via the Circ-Calm4/miR-124-3p/PDCD6 Axis.

Arteriosclerosis, thrombosis, and vascular biology

Jiang Y,Liu H,Yu H,Zhou Y,Zhang J,Xin W,Li Y,He S,Ma C,Zheng X,Zhang L,Zhao X,Wu B,Jiang C,Zhu D

Wed May 05 00:00:00 UTC 2021

Genetic screening of ANXA11 revealed novel mutations linked to amyotrophic lateral sclerosis.

Neurobiology of aging

Teyssou E,Muratet F,Amador MD,Ferrien M,Lautrette G,Machat S,Boillée S,Larmonier T,Saker S,Leguern E,Cazeneuve C,Marie Y,Guegan J,Gyorgy B,Cintas P,Meininger V,Le Forestier N,Salachas F,Couratier P,Camu W,Seilhean D,Millecamps S

Mon Mar 01 00:00:00 UTC 2021

Structural basis for dimerization quality control.

Nature

Mena EL,Jevtić P,Greber BJ,Gee CL,Lew BG,Akopian D,Nogales E,Kuriyan J,Rape M

Thu Oct 01 00:00:00 UTC 2020

PDCD6 cooperates with C-Raf to facilitate colorectal cancer progression via Raf/MEK/ERK activation.

Journal of experimental & clinical cancer research : CR

Wang X,Wu F,Wang H,Duan X,Huang R,Tuersuntuoheti A,Su L,Yan S,Zhao Y,Lu Y,Li K,Yao J,Luo Z,Guo L,Liu J,Chen X,Lu Y,Hu H,Li X,Bao M,Bi X,Du B,Miao S,Cai J,Wang L,Zhou H,Ying J,Song W,Zhao H

Mon Aug 03 00:00:00 UTC 2020

IL-27 posttranslationally regulates Y-box binding protein-1 to inhibit HIV-1 replication in human CD4+ T cells.

AIDS (London, England)

Poudyal D,Yang J,Chen Q,Goswami S,Adelsberger JW,Das S,Herman A,Hornung RL,Andresson T,Imamichi T

Tue Oct 01 00:00:00 UTC 2019

Triggered recruitment of ESCRT machinery promotes endolysosomal repair.

Science (New York, N.Y.)

Skowyra ML,Schlesinger PH,Naismith TV,Hanson PI

Fri Apr 06 00:00:00 UTC 2018

Triggered recruitment of ESCRT machinery promotes endolysosomal repair.

Science (New York, N.Y.)

Skowyra ML,Schlesinger PH,Naismith TV,Hanson PI

Fri Apr 06 00:00:00 UTC 2018

Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor.

Cell

McGourty CA,Akopian D,Walsh C,Gorur A,Werner A,Schekman R,Bautista D,Rape M

Thu Oct 06 00:00:00 UTC 2016

Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor.

Cell

McGourty CA,Akopian D,Walsh C,Gorur A,Werner A,Schekman R,Bautista D,Rape M

Thu Oct 06 00:00:00 UTC 2016

Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor.

Cell

McGourty CA,Akopian D,Walsh C,Gorur A,Werner A,Schekman R,Bautista D,Rape M

Thu Oct 06 00:00:00 UTC 2016

Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor.

Cell

McGourty CA,Akopian D,Walsh C,Gorur A,Werner A,Schekman R,Bautista D,Rape M

Thu Oct 06 00:00:00 UTC 2016

Luteinizing hormone inhibits cisplatin-induced apoptosis in human epithelial ovarian cancer cells.

Oncology letters

Xia L,Wen H,Han X,Tang J,Huang Y

Tue Mar 01 00:00:00 UTC 2016

Luteinizing hormone inhibits cisplatin-induced apoptosis in human epithelial ovarian cancer cells.

Oncology letters

Xia L,Wen H,Han X,Tang J,Huang Y

Tue Mar 01 00:00:00 UTC 2016

FSH inhibits ovarian cancer cell apoptosis by up-regulating survivin and down-regulating PDCD6 and DR5.

Endocrine-related cancer

Huang Y,Jin H,Liu Y,Zhou J,Ding J,Cheng KW,Yu Y,Feng Y

Tue Feb 01 00:00:00 UTC 2011

FSH inhibits ovarian cancer cell apoptosis by up-regulating survivin and down-regulating PDCD6 and DR5.

Endocrine-related cancer

Huang Y,Jin H,Liu Y,Zhou J,Ding J,Cheng KW,Yu Y,Feng Y

Tue Feb 01 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: ALG-2; ALG-257; Apoptosis-linked gene 2 protein; Apoptosis-linked gene 2 protein homolog; PMP41; probable calcium-binding protein ALG-2; Programmed cell death protein 6

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Gene Aliases: ALG-2; ALG2; AV299538; MA-3; PDCD6; PEF1B; PS2

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UniProt ID: (Human) O75340, (Rat) G3V7W1, (Mouse) P12815

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Entrez Gene ID: (Human) 10016, (Rat) 308061, (Mouse) 18570

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Function(s)

calcium-dependent cysteine-type endopeptidase activity calcium ion binding protein binding identical protein binding protein homodimerization activity protein anchor protein dimerization activity calcium-dependent protein binding binding, bridging metal ion binding

Process(es)

angiogenesis positive regulation of endothelial cell proliferation proteolysis intracellular protein transport activation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of endothelial cell migration negative regulation of vascular endothelial growth factor receptor signaling pathway negative regulation of TOR signaling cellular response to heat vascular endothelial growth factor receptor-2 signaling pathway positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of angiogenesis response to calcium ion negative regulation of protein kinase B signaling apoptotic signaling pathway apoptotic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PDCD6 Polyclonal Antibody

PDCD6 Antibody (12303-1-AP) in IHC (P)

Product Details

12303-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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