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Invitrogen
PDE10A Polyclonal Antibody
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Product Details
PA1-31145
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide (Human) taken against a common sequence near the 250-325 amino acids downstream of N-terminal region of PDE10A. Synthetic MAP.
Conjugate
Form
Liquid
Concentration
0.70 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
tris glycine, pH 7.4-7.9, with 30% glycerol, 0.5% BSA
Contains
0.02% Sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2162587
Product Specific Information
Recommended positive controls: For western blot - Rat brain and pancreas.
Target Information
Various cellular responses are regulated by the second messengers cAMP and cGMP. Phosphodiesterases, such as PDE10A, eliminate cAMP- and cGMP-mediated intracellular signaling by hydrolyzing the cyclic nucleotide to the corresponding nucleoside 5-prime monophosphate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; dJ416F21.1 (phosphodiesterase 10A); dual-substrate cAMP and cGMP, cyclic nucleotide phosphodiesterase; FLJ11894; FLJ25677; PDE10A2 brain-specific isoform; phosphodiesterase 10A1 (PDE10A1); phosphodiesterase 10A7 (PDE10A7); testis-specific phosphodiesterase PDE10A2
Gene Aliases: ADSD2; HSPDE10A; IOLOD; LINC00473; PDE10A; PDE10A19; Pde10a3
UniProt ID: (Human) Q9Y233, (Mouse) Q8CA95, (Rat) Q9QYJ6
Entrez Gene ID: (Human) 10846, (Mouse) 23984, (Rat) 63885
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
drug binding
cAMP binding
cGMP binding
metal ion binding
3',5'-cyclic-GMP phosphodiesterase activity
nucleotide binding
catalytic activity
cyclic-nucleotide phosphodiesterase activity
phosphoric diester hydrolase activity
hydrolase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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