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Product Details
PA5-32971
Product Specifications
Species Reactivity
Horse,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 17 amino acid peptide from internal region of human PDE3A.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2550432
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Mouse, Rat, Horse, Opossum (100%); Chicken (88%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
Cyclic nucleotide phosphodiesterases (PDEs) comprise a complex group of enzymes, and at least 5 major PDE families or classes with distinctive properties have been identified. Members of the cGMP-inhibited cAMP PDE (cGI-PDE) family, such as PDE3A, are characterized by high affinity for cAMP and cGMP and competitive inhibition of their cAMP hydrolytic activity by cGMP and certain positive inotropic agents (Meacci et al., 1992 [PubMed 1315035]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cAMP phosphodiesterase, myocardial cGMP-inhibited; cGI-PDE; CGI-PDE A; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A; cGMP-inhibited cAMP phosphodiesterase; cGMP-inhibited phosphodiesterase; Cyclic GMP-inhibited phosphodiesterase A; cyclic nucleotide phosphodiesterase; phosphodiesterase 3A, cGMP-inhibited
Gene Aliases: A930022O17Rik; C87899; CGI-PDE; CGI-PDE A; CGI-PDE-A; HTNB; PDE3A; RNPDE3A
UniProt ID: (Human) Q14432, (Mouse) Q9Z0X4, (Rat) Q62865
Entrez Gene ID: (Horse) 100034086, (Human) 5139, (Mouse) 54611, (Rat) 50678
3',5'-cyclic-AMP phosphodiesterase activity
cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
cAMP binding
metal ion binding
3',5'-cyclic-GMP phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
phosphoric diester hydrolase activity
hydrolase activity
cyclic-nucleotide phosphodiesterase activity
oocyte maturation
cAMP catabolic process
signal transduction
cAMP-mediated signaling
cGMP-mediated signaling
regulation of meiotic nuclear division
response to drug
negative regulation of apoptotic process
negative regulation of vascular permeability
positive regulation of vascular permeability
positive regulation of oocyte development
cellular response to cGMP
diterpenoid metabolic process
response to cAMP
cellular response to transforming growth factor beta stimulus
lipid metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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