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Product Details
PD4-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide common to most PDE4 subtypes: PDE4A, PDE4D, PDE4B
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
A phosphodiesterase-4 inhibitor, commonly referred to as a PDE4 inhibitor, is a drug used to block the degradative action of phosphodiesterase 4 on cyclic adenosine monophosphate. It is a member of the larger family of PDE inhibitors. The PDE4 family of enzymes are the most prevalent PDE in immune cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3',5'-cyclic-AMP phosphodiesterase 4A; 3',5'-cyclic-AMP phosphodiesterase 4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4A; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4A; cAMP-specific phosphodiesterase PDE4D; cAMP-specific phosphodiesterase PDE4D6; cAMP-specific phosphodiesterase splice variant PDE4D8; cyclic AMP specific phosphodiesterase PDE4A5A; cyclic AMP specific phosphodiesterase PDE4D5A; DPDE2; DPDE3; dunce; PDE43; PDE46; phosphodiesterase 4A, cAMP specific; phosphodiesterase 4A, cAMP-specific (dunce; phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila); Phosphodiesterase 4D cAMP-specific (dunce; phosphodiesterase 4D, cAMP specific; Phosphodiesterase 4D, cAMP-specific (dunce; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); phosphodiesterase E2 dunce homolog, Drosophila; phosphodiesterase isozyme 4; testicular tissue protein Li 136
Gene Aliases: 9630011N22Rik; ACRDYS2; D9Ertd60e; DPDE2; DPDE3; HSPDE4D; PDE4; PDE43; PDE46; PDE4A; PDE4D; PDE4DN2; PHOSA; RCJMB04_2o18; STRK1
UniProt ID: (Human) P27815, (Human) Q08499, (Mouse) O89084, (Rat) P54748, (Rat) P14270, (Mouse) Q01063
Entrez Gene ID: (Human) 5141, (Chicken) 769469, (Human) 5144, (Mouse) 18577, (Rat) 25638, (Rat) 24627, (Mouse) 238871
3',5'-cyclic-AMP phosphodiesterase activity
protein binding
cAMP binding
metal ion binding
3',5'-cyclic-nucleotide phosphodiesterase activity
drug binding
enzyme binding
beta-2 adrenergic receptor binding
ion channel binding
ATPase binding
scaffold protein binding
phosphoric diester hydrolase activity
hydrolase activity
cyclic-nucleotide phosphodiesterase activity
SH3 domain binding
protein domain specific binding
ubiquitin protein ligase binding
regulation of heart rate
cAMP catabolic process
smooth muscle contraction
aging
memory
regulation of G-protein coupled receptor protein signaling pathway
regulation of receptor activity
regulation of protein kinase A signaling
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
positive regulation of smooth muscle cell migration
lung development
neutrophil chemotaxis
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
positive regulation of interleukin-5 production
negative regulation of peptidyl-serine phosphorylation
multicellular organism growth
cellular protein complex assembly
negative regulation of heart contraction
positive regulation of smooth muscle cell proliferation
T cell receptor signaling pathway
leukocyte migration
regulation of ryanodine-sensitive calcium-release channel activity
establishment of endothelial barrier
cellular response to lipopolysaccharide
cellular response to cAMP
cellular response to epinephrine stimulus
adrenergic receptor signaling pathway
regulation of cardiac muscle cell contraction
adrenergic receptor signaling pathway involved in positive regulation of heart rate
negative regulation of relaxation of cardiac muscle
signal transduction
sensory perception of smell
cellular response to drug
regulation of cAMP-mediated signaling
metabolic process
response to drug
regulation of cell communication by electrical coupling involved in cardiac conduction
cAMP-mediated signaling
regulation of cAMP metabolic process
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