Proteintech

PDE4A Polyclonal Antibody

PDE4A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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PDE4A Antibody (16226-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human placenta using 16226-1-AP (PDE4A antibody) at dilution of 1:50 (under 40x lens).

PDE4A Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

16226-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PDE4A Fusion Protein Ag8018 (297-647 aa encoded by BC019864)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MVIDMVLAT DMSKHMTLLA DLKTMVETKK VTSSGVLLLD NYSDRIQVLR NMVHCADLSN PTKPLELYRQ WTDRIMAEFF QQGDRERERG MEISPMCDKH TASVEKSQVG FIDYIVHPLW ETWADLVHPD AQEILDTLED NRDWYYSAIR QSPSPPPEEE SRGPGHPPLP DKFQFELTLE EEEEEEISMA QIPCTAQEAL TAQGLSGVEE ALDATIAWEA SPAQESLEVM AQEASLEAEL EAVYLTQQAQ STGSAPVAPD EFSSREEFVV AVSHSSPSAL ALQSPLLPAW RTLSVSEHAP GLPGLPSTAA EVEAQREHQA AKRACSACAG TFGEDTSALP APGGGGSGGD PT (297-647 aa encoded by BC019864)

Target Information

Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. PDE4A is a class IV cAMP-specific PDE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia.

Cellular signalling

Wendimu MY,Alqinyah M,Vella S,Dean P,Almutairi F,Davila-Rivera R,Rayatpisheh S,Wohlschlegel J,Moreno S,Hooks SB

Thu Jul 01 00:00:00 UTC 2021

Phosphodiesterases Expression during Murine Cardiac Development.

International journal of molecular sciences

Carvalho TMDCS,Cardarelli S,Giorgi M,Lenzi A,Isidori AM,Naro F

Fri Mar 05 00:00:00 UTC 2021

Involvement of 3',5'-cyclic inosine monophosphate in cystathionine γ-lyase-dependent regulation of the vascular tone.

British journal of pharmacology

Mitidieri E,Vellecco V,Brancaleone V,Vanacore D,Manzo OL,Martin E,Sharina I,Krutsenko Y,Monti MC,Morretta E,Papapetropoulos A,Caliendo G,Frecentese F,Cirino G,Sorrentino R,d'Emmanuele di Villa Bianca R,Bucci M

Wed Sep 01 00:00:00 UTC 2021

Inhibition of PDE4/PDE4B improves renal function and ameliorates inflammation in cisplatin-induced acute kidney injury.

American journal of physiology. Renal physiology

Xu M,Yu X,Meng X,Huang S,Zhang Y,Zhang A,Jia Z

Sun Mar 01 00:00:00 UTC 2020

DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling.

Biochemical pharmacology

Li H,Li J,Zhang X,Feng C,Fan C,Yang X,Zhang R,Zhu F,Zhou Y,Xu Y,Liu H,Tang W

Wed Jul 01 00:00:00 UTC 2020

Apremilast Normalizes Gene Expression of Inflammatory Mediators in Human Keratinocytes and Reduces Antigen-Induced Atopic Dermatitis in Mice.

Drugs in R&D

Schafer PH,Adams M,Horan G,Truzzi F,Marconi A,Pincelli C

Sun Dec 01 00:00:00 UTC 2019

Phosphodiesterase 4 in inflammatory diseases: Effects of apremilast in psoriatic blood and in dermal myofibroblasts through the PDE4/CD271 complex.

Cellular signalling

Schafer PH,Truzzi F,Parton A,Wu L,Kosek J,Zhang LH,Horan G,Saltari A,Quadri M,Lotti R,Marconi A,Pincelli C

Fri Jul 01 00:00:00 UTC 2016

Phosphodiesterase 4 in inflammatory diseases: Effects of apremilast in psoriatic blood and in dermal myofibroblasts through the PDE4/CD271 complex.

Cellular signalling

Schafer PH,Truzzi F,Parton A,Wu L,Kosek J,Zhang LH,Horan G,Saltari A,Quadri M,Lotti R,Marconi A,Pincelli C

Fri Jul 01 00:00:00 UTC 2016

Phosphodiesterase 4 in inflammatory diseases: Effects of apremilast in psoriatic blood and in dermal myofibroblasts through the PDE4/CD271 complex.

Cellular signalling

Schafer PH,Truzzi F,Parton A,Wu L,Kosek J,Zhang LH,Horan G,Saltari A,Quadri M,Lotti R,Marconi A,Pincelli C

Fri Jul 01 00:00:00 UTC 2016

Phosphodiesterase 4 in inflammatory diseases: Effects of apremilast in psoriatic blood and in dermal myofibroblasts through the PDE4/CD271 complex.

Cellular signalling

Schafer PH,Truzzi F,Parton A,Wu L,Kosek J,Zhang LH,Horan G,Saltari A,Quadri M,Lotti R,Marconi A,Pincelli C

Fri Jul 01 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: 3',5'-cyclic-AMP phosphodiesterase 4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A; cAMP-specific phosphodiesterase 4A; cAMP-specific phosphodiesterase PDE4A; cyclic AMP specific phosphodiesterase PDE4A5A; DPDE2; dunce; PDE46; phosphodiesterase 4A, cAMP specific; phosphodiesterase 4A, cAMP-specific (dunce; phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila); phosphodiesterase E2 dunce homolog, Drosophila; phosphodiesterase isozyme 4

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Gene Aliases: D9Ertd60e; DPDE2; PDE4; PDE46; PDE4A; PHOSA

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UniProt ID: (Human) P27815, (Mouse) O89084, (Rat) P54748

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Entrez Gene ID: (Human) 5141, (Mouse) 18577, (Rat) 25638

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Function(s)

3',5'-cyclic-AMP phosphodiesterase activity protein binding cAMP binding metal ion binding 3',5'-cyclic-nucleotide phosphodiesterase activity phosphoric diester hydrolase activity hydrolase activity

Process(es)

cAMP catabolic process signal transduction sensory perception of smell regulation of protein kinase A signaling cellular response to drug regulation of cAMP-mediated signaling metabolic process response to drug

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PDE4A Polyclonal Antibody

PDE4A Antibody (16226-1-AP) in IHC (P)

Product Details

16226-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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